IL-6、PCT、hs-CRP和WBC在新生儿细菌感染性疾病早期诊断中的价值

目的 深入探讨白细胞介素-6(IL-6)、血清降钙素原(PCT)、超敏C反应蛋白(hs-CRP)和白细胞计数(WBC)在新生儿细菌感染性疾病早期诊断中的价值,为临床采取及时有效的治疗措施提供科学依据.方法 选取2018年6月—2018年10月在山东第一医科大学第二附属医院新生儿科住院诊断为细菌感染性疾病的69例新生儿作...

The value of interleukin-6, procalcitonin, high-sensitivity C-reactive protein and white blood cell count in the early diagnosis of neonatal bacterial infection

Objective To deeply explore the value of interleukin-6 (IL-6), serum procalcitonin (PCT), high-sensitive C-reactive protein (hs-CRP) and white blood cell (WBC) count in the early diagnosis of neonatal bacterial infection, so as to provide scientific evidence for effective and timely clinical treatment.Methods A total of 69 neonates with bacterial infectious diseases admitted to the Second Affiliated Hospital of Shandong First Medical University from June 2018 to October 2018 were selected as the infection group, while 45 neonates without bacterial infectious diseases in the hospital during the same time were enrolled as the control group. The serum levels of IL-6, hs-CRP, and PCT as well as WBC count were compared between the two groups, and the areas under the receiver operating characteristic (ROC) curve, sensitivity and specificity of each indicator for the diagnosis of neonatal bacterial infection were also analyzed.Results There was no difference in the sex ratio, days of age, gestational age or birth weight between the two groups of neonates (P > 0.05). The WBC count and the levels of IL-6, PCT, and hs-CRP in the infection group were higher than those in the control group (P < 0.05). The positive rates of the WBC count, IL-6, PCT, and hs-CRP in the infection group were also higher than those in the control group (P < 0.05). In the ROC analysis, compared with other indicators, the Youden index (0.743) and the area under the ROC (AUC) curve (0.967) of IL-6 were the highest, respectively. As for the combination detection, the specificity of WBC combined with hs-CRP (82.22%), the sensitivity of PCT, IL-6, WBC combined with hs-CRP (98.55%), and the Youden index of IL-6, WBC combined with hs-CRP were the highest, respectively.Conclusions The detection of IL-6, PCT, hs-CRP, and WBC count is of certain significance in the early diagnosis of neonatal bacterial infection. Specifically, the combined detection of different indicators may play an important role in early diagnosing neonatal bacterial infection with all sorts of clinical manifestations.