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肺移植术后早期急性肾损伤的研究进展
引用本文:陈奥, 练巧燕, 徐鑫, 等. 肺移植术后早期急性肾损伤的研究进展[J]. 器官移植, 2020, 11(6): 743-748. doi: 10.3969/j.issn.1674-7445.2020.06.015
作者姓名:陈奥  练巧燕  徐鑫  韦兵  刘梦杨  彭桂林  张建恒  何建行  巨春蓉
作者单位:510012 广州医科大学附属第一医院移植科 广州呼吸健康研究院
摘    要:
急性肾损伤(AKI)是肺移植术后早期常见并发症之一,AKI不仅导致肺移植受者术后近期及远期病死率增加,且显著增加术后远期慢性肾功能不全的发生率。近年来,随着肺移植在中国的迅速发展,肺移植术后早期AKI也引起高度关注。本文对近年来国际上关于肺移植术后早期AKI的诊断、发生情况、危险因素、防治等方面的研究进展进行综述,旨在更好地识别肺移植术后早期AKI相关的危险因素及其不良预后,为临床早期干预提供理论及实践指导。

关 键 词:肺移植   急性肾损伤   持续性肾脏替代治疗   体外膜肺氧合   机械通气   血清肌酐   肾小球滤过率   中性粒细胞明胶酶相关脂质运载蛋白
收稿时间:2020-08-18

Research progress on early acute kidney injury after lung transplantation
Chen Ao, Lian Qiaoyan, Xu Xin, et al. Research progress on early acute kidney injury after lung transplantation[J]. ORGAN TRANSPLANTATION, 2020, 11(6): 743-748. doi: 10.3969/j.issn.1674-7445.2020.06.015
Authors:Chen Ao  Lian Qiaoyan  Xu Xin  Wei Bing  Liu Mengyang  Peng Guilin  Zhang Jianheng  He Jianxing  Ju Chunrong
Affiliation:Department of Transplantation, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, Guangzhou 510012, China
Abstract:
Acute kidney injury (AKI) is one of the common early complications after lung transplantation, which not only increases the short-term and long-term fatality of lung transplant recipients, but also significantly increases the incidence of long-term chronic renal insufficiency after surgery. In recent years, early AKI after lung transplantation has attracted high attention along with the rapid development of lung transplantation in China. In this article, research progresses on diagnosis, incidence, risk factors, prevention and treatment of early AKI after lung transplantation around the globe were reviewed, aiming to better identify the risk factors and poor prognosis of early AKI after lung transplantation, and provide theoretical and practical guidance for early clinical interventions.
Keywords:Lung transplantation  Acute kidney injury  Continuous renal replacement therapy  Extracorporeal membrane oxygenation  Mechanical ventilation  Serum creatinine  Glomerular filtration rate  Neutrophil gelatinase associated lipocalin
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