| 脑梗死患者血清白细胞介素-10、白细胞介素-8的动态变化及相关研究 |
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| 引用本文： | 高瑞利,左平祥,张国华,蒋欣,刘希奇,张宁,王冬欣.脑梗死患者血清白细胞介素-10、白细胞介素-8的动态变化及相关研究[J].中国综合临床,2008,24(7):634-636. |
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| 作者姓名： | 高瑞利 左平祥 张国华 蒋欣 刘希奇 张宁 王冬欣 |
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| 作者单位： | 1. 河北医科大学第二医院神经内科, 石家庄,050000
2. 河北省灵寿县医院内科 |
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| 基金项目： | 河北省卫生厅医学科研项目，河北省科技攻关项目 |
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| 摘 要： | 目的 探讨脑梗死患者血清抗炎因子白细胞介素-10(IL-10)和炎性因子白细胞介素-8(IL-8)的变化规律及临床意义.方法 采用双抗体夹心酶联免疫吸附法(ELISA)定量测定30例脑梗死患者发病第1、3、7、14天和30例正常对照组的血清IL-10、IL-8水平.结果 脑梗死组IL-10在发病后第1、3、7、14天显著高于正常对照组(12.69±4.90)、(16.75±5.16)、(13.71±5.66)、(13.68±4.80)ng/L vs(8.76±4.22)ng/L;q1=4.32,q3=8.80,q7=5.45,q14=5.42,均P<0.01);IL-8在发病后第1、3、7天显著高于正常对照组(32.38±17.11)、(33.71±19.86)、(43.92±18.54)ng/L vs(20.25±12.17)ng/L;q1=3.93,q3=4.36,q7=7.67,均P<0.01);IL-10与IL-8不相关.结论 IL-10、IL-8 均参与急性脑梗死的病理生理过程.
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| 关 键 词： | 脑梗死 白细胞介素-10 白细胞介素-8 |
Changes and correlation of serum interleukin-10 and interleukin-8 levels in the patients with cerebral infarction |
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| GAO Rui-li,ZUO Ping-xiang,ZHANG Guo-hua,JIANC Xin,LIU Xi-qi,ZHANG Ning,WANG Dong-xin.Changes and correlation of serum interleukin-10 and interleukin-8 levels in the patients with cerebral infarction[J].Clinical Medicine of China,2008,24(7):634-636. |
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| Authors: | GAO Rui-li ZUO Ping-xiang ZHANG Guo-hua JIANC Xin LIU Xi-qi ZHANG Ning WANG Dong-xin |
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| Abstract: | Objective To explore the clinical significance and the dynamic changes of serum anti-inflam-mation factor interleukin-10(IL-10)and inflammatory factor interleukin-8(IL-8)in cerebral infarction.Methods The serum levels of IL-10 and IL-8 in 30 patients were measured by double-antibody sandwich enzyme-linked inunu-nosorbent assay(ELISA)on days 1.3,7 and 14 respectively after infarction.Results The serum levels of IL-10 and IL-8 were higher in patients than those in control group on days 1,3 and 7(P<0.05).Conclusion IL-10 and IL-8 are involved in the pathophysiology of acute cerebral infarction. |
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| Keywords: | Cerebral Infarction Interleukin-10 Interleukin-8 |
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