Mécanismes de la dénutrition au cours de l'insuffisance respiratoire chronique

The study of the mechanisms of denutrition during chronic obstructive pulmonary disease is useful because this common evolutive complication has severe functional consequences and is associated with a poor prognosis, irrespective of respiratory functional status. Conversely, renutrition improves the prognosis in these patients. Adaptation to hypoxia, the basis of which is oxygen conformance, is described. Denutrition during chronic obstructive pulmonary disease is linked to the imbalance arising from increased energy expenditure and inadequate food intake. The origins of the imbalance are discussed. The clinical implications of knowing the mechanisms of denutrition are set out and perspectives for both experimental and applied research are proposed.