冠心病患者血清高敏C反应蛋白和Periostin蛋白与冠状动脉病变严重程度的相关性

目的测定冠心病患者血清高敏C反应蛋白与Periostin蛋白水平,研究其与冠状动脉狭窄程度的相关性。方法采用酶联免疫吸附法测定87例冠心病患者血清高敏C反应蛋白和Periostin蛋白水平,其中急性心肌梗死57例,不稳定型心绞痛30例,分析两组间高敏C反应蛋白和Periostin蛋白表达的相关性。根据造影结果对冠状动脉狭窄程度进行Gensini评分,分析高敏C反应蛋白和Periostin蛋白水平与冠状动脉狭窄严重程度的关系。结果急性心肌梗死患者血清高敏C反应蛋白和Periostin蛋白水平显著高于不稳定型心绞痛患者(P<0.05或P<0.001)。高敏C反应蛋白(r=0.232,P<0.05)和Periostin蛋白水平(r=0.624,P<0.001)随冠状动脉Gensini评分增高而升高,呈正相关。血清高敏C反应蛋白与Periostin蛋白水平呈正相关(r=0.223,P<0.05)。结论血清高敏C反应蛋白和Periostin蛋白水平在冠心病急性心肌梗死患者较不稳定型心绞痛患者中显著增高,其水平与冠状动脉狭窄程度呈正相关,能较好的反映疾病的严重程度,预测病情。

Association of Serum High Sensitivity C-Reactive Protein and Periostin Protein with Coronary Artery Stenosis in Coronary Heart Disease

AimTo investigate the association of serum high sensitivity C-reactive protein (hs-CRP) and Periostin protein with coronary artery stenosis in coronary heart disease patients.MethodsSerum hs-CRP and Periostin protein were measured using enzyme-linked immunosorbent assay (ELISA) in 87 patients with coronary heart disease, of which 57 patients were diagnosed as acute myocardial infarction (AMI) and 30 were unstable angina pectoris (UAP).Coronary artery stenosis was characterized by Gensini scores.ResultsSerum hs-CRP and Periostin protein were significantly increased in AMI patients compared with UAP (P<0.05 or P<0.001) and they were in positive correlation with Gensini score (P<0.05 or P<0.001).The two protein were also in positive correlation with each other (P<0.05).