艾司西泰普兰联合坦度螺酮对老年女性冠心病合并焦虑抑郁障碍共病患者的疗效

目的观察艾司西泰普兰联合坦度螺酮对老年(≥60岁)女性冠心病合并焦虑抑郁障碍共病患者的治疗效果。方法选取合并焦虑抑郁共病的老年女性冠心病患者100例为研究对象,随机分为治疗组(50例)和对照组(50例),使用汉密尔顿焦虑量表(HAMA)和汉密尔顿抑郁量表(HAMD)评价入选者焦虑及抑郁严重程度,观察治疗前后患者焦虑抑郁量表评分变化及心绞痛、心律失常、急性心肌梗死发生情况及药物安全性等。结果老年女性冠心病伴焦虑抑郁障碍共病患者常规治疗基础上加用艾司西泰普兰联合坦度螺酮后,HAMA评分减少量治疗组(14.07±5.39)显著高于对照组减少量(7.19±4.81)(P<0.05),HAMD评分减少量治疗组(14.59±6.76)明显高于对照组(7.28±6.27),差异有统计学意义(P<0.05);治疗组冠心病不良事件心绞痛再发率、急性心肌梗死发生率、严重心律失常发生率分别为4.54%、0%和6.82%,对照组分别为16.28%、2.33%和18.60%,治疗组冠心病不良事件发生率明显低于对照组(P<0.05),且药物安全性较好。结论老年女性冠心病合并焦虑抑郁障碍共病患者加用艾司西泰普兰联合坦度螺酮治疗,可能获得较好收益,改善预后。

Effect Observation on Escitalopram Joint Tandospirone in Treating Older Women Patients with Coronary Heart Disease Complicating Anxiety Disorder Combined Depression Disorder

Aim To observed the efficacy of Escitalopram joint Tandospirone in treating older women patients with coronary heart disease complicating anxiety disorder combined depression disorder.Methods The 100 older women patients with coronary heart disease complicating anxiety disorder combined depressio.disorder selected as the research object,were randomly divided into treatment group (50 cases) and the control group (50 cases). Hamilton anxiety scale (HAMA) and Hamilton depression scale (HAMD) were used to evaluate severity entrants of anxiety and depression of the patients. The changes of anxiety depression rating scale,angina pectoris,arrhythmia and acute myocardial infarction occurred situation before and after treatment in patients,drug safety,etc were observed.Results After Escitalopram joint Tandospirone treating in older women patients with coronary heart disease complicating anxiety disorder combined depression disorder based on routine treatment,the HAMA scores reducion was significantly higher in treatment group (14.07±5.39) than that in control group (7.19±4.81 P<0.05) The HAMD scores reducion were significantly higher in treatment group (14.59±6.76)than that in control group (7.28±6.27 P<0.05). The recurrence rate of coronary heart disease angina adverse events including angina pectoris,acute myocardial infarction,severe arrhythmia were 4.54%,0%,6.82% respectively in treatment group,they were 16.28%,2.33%,18.60% in control group,the coronary heart disease events of the treatment group were significantly lower than those in control group (P<0.05),and the drug safety was better.Conclusions Additional treatment of Escitalopram joint Tandospirone in older women patients with coronary heart disease complicating anxiety disorder combined depression disorder,may obtain a better benefit,improve the recovery.