蟾蜍血清酶对梭曼中毒小鼠的防治

作者证明了蟾蜍血清对梭曼中毒小鼠有解毒作用,预防效果最显著.血清酶先由静脉注入43个酶活力单位,然后于1～10h不同时间中毒,动物可100%存活.如用于治疗,则在中毒前20min先于腹腔注入阿托品10mg/kg,在梭曼皮下中毒3min后,再于静脉注入43个酶活力单位,则动物存活率为80%,而阿托品单药在1～20mg/kg范围内的不同剂量动物均死亡.当重复中毒时,先于静脉注入43个酶活力单位,每隔15min注入1LD梭曼,则动物可耐受6～7次梭曼中毒,耐受总剂量达1.2～1.4mg/kg,而97只中毒对照全部死亡.

PROTECTIVE AND THERAPEUTIC EFFECTS OF TOAD SERUM ON SOMAN POISONED MICE

It was found that the toad serum enzyme demonstrated a detoxifying effect against soman poisoning in mice.The effect was prominent when the serum was given prophylactically. Pretreated with 43 enzyme units intravenously at various intervals of 1-10 hours before soman poisoning,the mice 100% survived.Given a dose of 10mg/kg of atropine i.p.20 minutes before soman intoxication by s.c. route and 43 enzyme units 3 minutes after soman poisoning,80% animals survived.Given 1-20mg/kg of atropine alone,animals all died.Pretreated with 43 enzyme units intravenously,the mice could tolerate repeated intoxication with 1 LD soman for 6-7 times at intervals of 15 minutes.Thus a total dose of soman which can be tolerated was approximately 1.2-1.4mg/kg,while 97 control animals all died.