Shuttle-box avoidance facilitation by minaprine in mice

The effects on shuttle-box avoidance acquisition of the new antidepressant minaprine (1, 2.5, 5 or 10 mg/kg) and of the classical antidepressant desipramine (0.5, 1, 2.5 or 5 mg/kg) were tested, without pretreatment or after a 5 day pretreatment, in mice of the CD-1 strain, subjected to five daily 100-trial training sessions. Minaprine, recently proposed as a new nootropic agent, facilitated avoidance performance when given to pretreated animals at a dose of 10 mg/kg, which had no effect on spontaneous locomotor activity. Desipramine did not exert any significant effect on avoidance responses. The results are in agreement with previous findings showing learning improvements by minaprine, but do not clarify the mechanism involved in the avoidance facilitation.