放射性核素胃食管显像检测新生儿 胃排空和胃食管反流

目的　采用放射性核素胃食管显像评价新生儿胃排空和胃食管反流情况。方法　 77例处于疾病恢复期的新生儿患者 ,其中足月儿 46例、早产儿 31例。用胃食管显像测定 6 0min胃排空率 (GE6 0 % )和胃食管反流指数 (RI)。结果　所有患儿均未发现不良反应。早产儿的胃排空率 [(2 8 3± 7 7) % ]明显低于足月儿 [(4 9 2± 12 8) % ],P <0 0 0 1。胎龄与胃排空率间存在正相关关系。足月儿无症状反流率为 6 0 9% (2 8 46例 ) ,早产儿中高达 83 9% (2 6 31例 ) ,差异有显著性 (P <0 0 5 )。结论　胃食管显像检测新生儿胃排空和胃食管反流是可行的 ;早产儿的胃排空率低于足月儿 ,正常新生儿中存在一定比例的无症状胃食管反流

The determination of neonatal gastric emptying and gastroesophageal reflux with radionuclide gastroesophageal scintigraphy

Objective　To evaluate neonatal gastric emptying and gastroesophageal reflux with gastroesophageal scintigraphy. Methods　Gastrointestinal motility was expressed as gastric emptying rate at 60 min after feeding (GE60%) and reflux index (RI) on 99　Tcm-DTPA gastroesophageal scintigraphy. 77 normal neonates were enrolled in this study. Results　GE60% in preterm infants was lower than that in full-term neonates (28.3%±7.7% vs 49.2%±12.8%). Gestational age was positively correlated to gastric emptying rate. Asymptomatic gastroesophageal reflux was 60.9% in 46 full-term neonates and 83.9% in 31 preterm infants, P<0.05. Conclusions　Gastroesophageal scintigraphy can be used to examine neonatal gastric emptying and gastroesophageal reflux. Preterm infants have lower GE60% than that in full-term neonates. There is a considerable incidence of asymptomatic gastroesophageal reflux in normal neonates.