Larger Brains in Medication Naive High-Functioning Subjects with Pervasive Developmental Disorder |
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| Authors: | Saskia?J.?M.?C.?Palmen mailto:s.palmen@azu.nl" title=" s.palmen@azu.nl" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,Hilleke?E.?Hulshoff Pol,Chantal?Kemner,Hugo ?G.?Schnack,Joost?Janssen,René?S.?Kahn,Herman?van Engeland |
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| Affiliation: | (1) Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, HP A01.468, 3584 CX Utrecht, The Netherlands;(2) Department of Psychiatry, Rudolf Magnus Institute Of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands |
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| Abstract: | ![]()
Background: Are brain volumes of individuals with Pervasive Developmental Disorder (PDD) still enlarged in adolescence and adulthood, and if so, is this enlargement confined to the gray and/or the white matter and is it global or more prominent in specific brain regions.Methods: Brain MRI scans were made of 21 adolescents with PDD and 21 closely matched controls. Results: All brain volumes, except the white matter, were significantly larger in patients. After correction for brain volume, ventricular volumes remained significantly larger in patients. Conclusions: Patients showed a proportional, global increase in gray matter and cerebellum volume, and a disproportional increase in ventricular volumes. Thus, at least in high-functioning patients with PDD, brain enlargement may still be present in adult life. |
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| Keywords: | Brain MRI autism gray matter white matter cortical lobes |
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