D-二聚体在不同类型和病期主动脉夹层患者中的检测结果分析

目的:测定不同类型和病期的主动脉夹层患者血浆D-二聚体水平,探讨D-二聚体对主动脉夹层诊断和评估的价值。方法:共收入近3年来经治的49例主动脉夹层患者,根据影像特征分为4组,分别测定其急性期和慢性期的D-二聚体水平;同时测定通过介入技术行主动脉腔内隔绝治疗术后1d和7d的D-二聚体水平。以急性心肌梗死、动脉瘤及非器质性心肺疾病胸痛患者作为对照。分析D-二聚体在不同类型患者中的临床意义。结果:急性主动脉夹层形成后D-二聚体水平显著升高,D-二聚体检测在夹层不同病期和不同类别中存在显著差异,腔内隔绝术也会显著升高D-二聚体水平。结论:D-二聚体的水平有助于对不同类型、不同病期和介入治疗的主动脉夹层患者进行合理诊断和评估。

Analysis of D-dimer in different types and stages of aortic dissection

Objective:To investigate the D-dimer level in different types and stages of aortic dissection, and further to determine the value of D-dimer in diagnosis and evaluation of aortic dissection.Method:Forty-nine patients with aortic dissection were divided into four groups and the D-dimer was tested in acute and chronic stages. D-dimer was assayed after stent-graft endovascular exclusion. The patients with acute myocardial infarction, aortic aneurysm, and chest pain without severe heart or lung disease were served as controls. The clinical significance of D-dimer in patients with aortic dissection was analyzed.Result:The D-dimer were significantly higher in acute aortic dissection than in chronic ones and controls, and in different types of aortic dissection, there were significant differences too. The D-dimer increased significantly after endovascular exclusion.Conclusion:The D-dimer is a useful molecular marker in the diagnosis of aortic dissection. The D-dimer level is helpful to completely and properly diagnose and evaluate the aortic dissection in different types and stages.