| 口腔颌面部肿瘤化疗方案药物敏感性试验 |
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| 引用本文： | 孙春晓 杨明达. 口腔颌面部肿瘤化疗方案药物敏感性试验[J]. 现代口腔医学杂志, 1997, 11(4): 253-255 |
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| 作者姓名： | 孙春晓 杨明达 |
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| 作者单位： | 浙江医科大学附属第二医院口腔科 310009上海第二医科大学附属第九医院口腔颌面外科200011(孙春晓)，浙江医科大学附属第二医院口腔科 310009(杨明达，黄剑奇)，浙江医科大学微生物学教研室 310006(蔡挺) |
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| 摘 要： | 尊文以人舌鳞癌细胞系Ｔｃａ８１１３为对象，利用ＭＴＴ法对口腔颌面部肿瘤化疗常用的八种药物和七种方案进行了药敏试验，ＡＤＭ、５－Ｆｕ、ＣＤＤＰ等抗肿瘤作用较强；而ＰＹＭ、ＭＴＸ、ＶＣＲ单用对Ｔｃａ８１１３细胞无明显作用。化疗方案中以ＭＭＢＤ、ＰＦ、ＰＶＰ方案为佳，卡铂与顺铂在此疗方案中的作用无明显差异。实验结果提示：肿瘤化疗不能只凭经验用药，应注意化疗的耐药性问题。
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| 关 键 词： | 口腔肿瘤 颌面部肿瘤 药物疗法 药敏试验 |
Drug Sensitivity of Chemotherapeutic Methods in Tongue Squamous Cell Carcinoma with MTT Assay |
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| Sun Chunxiao,Yang Mingda,Huang Jianqi,et al. Drug Sensitivity of Chemotherapeutic Methods in Tongue Squamous Cell Carcinoma with MTT Assay[J]. Journal of Modern Stomatology, 1997, 11(4): 253-255 |
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| Authors: | Sun Chunxiao Yang Mingda Huang Jianqi et al |
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| Affiliation: | Sun Chunxiao,Yang Mingda,Huang Jianqi,et alDepartment of Oral and Maxillo facial Surgery the second hospital ofZhejian Medical University,HangZhou 310009 |
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| Abstract: | How to select a/some sensitive drug(s) to certain cancer is a big problem. In this paper, we reported the drug sensitivities of 8 anticancer drugs and 7 chemotherapeutic methods frequently used in oral cancer with MTT assay. ADM, 5-Fu, and CDDP have better effects on tongue squarnous cell carcinoma cell line Tca8113 in vitro, but PYM, MTX, VCR have no significant effect on it. In 7 chemotherapeutic methods, MMBD, PF and PVP methods can inhibit the growth of Tca8113 cell rapidly in vitro. However, VM method can hardly inhibit the cell growth. BM and PM methods inhibit the cell just a little more than 50%. The results indicate jn order to eleminate drug resistance and get best effect of drug treatment, we should choose the drug carefully and scientificly. |
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| Keywords: | anticancer drug sensitivity head and neck carcinoma MTT assay |
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