“一步法”诊断妊娠期糖尿病研究

多肽药物因具有相对成本低，生物活性强，副作用小，不蓄积中毒，作用靶点专一等特点而被人们广泛应用。但天然存在的多肽类药物含量较少、纯度较低，无法满足临床的需求。经研究发现，通过体外合成的多肽药物具有合成周期短、生产量大等优势，能够有效克服天然多肽药物的不足，对于推广多肽类药物的应用有重要意义。本文对多肽类药物体外合成方法进行综述，为其今后的发展和临床应用提供参考。

Research of gestational diabetes situation under the "one-step"diagnosis

Peptide drugs have been widely used for the low cost , high biological activity, low side effects, no accumulation of toxic, target specificity and other s .However, the natural peptide drugs have low concentration and low purity;can not meet the requirement of clinical applications .Synthetic peptide drugs have the priority of short synthetic cycle and large production volume , which are important for the promotion of clinical application of peptide drugs .Consulting the relevant literatures , this article intends to review the drugs synthesis and provide a reference for future drug development and clinical application .