α-葡萄糖苷酶抑制剂筛选模型的研究进展

α-葡萄糖苷酶抑制剂(alpha-glucosidase inhibitors,α-GI)是可用于治疗2型糖尿病的一类新型药物,广泛存在于植物果实、叶片和种子等组织器官中。近15年来,国内外从中草药中寻找新的α-GI的研究渐趋活跃,逐渐成为防治糖尿病的热点。随着α-GI的不断发现,构建更加符合人体糖尿病病理生理特征、更加具有临床意义的α-GI高通量体外筛选模型,对降糖药的研发具有重要的意义。本文综述了以中草药为来源的α-GI筛选研究进展,并对各种方法存在的问题和今后研究思路进行了探讨。

Progress on research of screening methods for alpha-glucosidase inhibitors from Chinese medicinal herbs

Alpha-glucosidase inhibitors are novel hypoglycemic drugs which have been used in the treatment of type 2 diabetes mellitus since 1980s.It has long been realized that many naturally occurring substances in plant materials such as fruits,leaves,seeds etc,have inhibitory effect on alpha glucosidase.Recently,the research of screening new alpha-glucosidase inhibitors both at home and abroad has become popular and the topic for treating and prevention of diseases including diabetes mellitus.With increasing discovery of alpha-glucosidase inhibitors,it is necessary to construct a reliable high-throughput way for screening alpha-glucosidase inhibitors.Such action may help the development of a potential functional factor for lowering blood glucose.In this paper the advance of screening models for alpha-glucosidase inhibitors from Chinese herbal drugs and their drawbacks are reviewed,the future way of research in this field is also discussed.