颞下颌关节盘前移位关节区组织病理变化的实验研究

目的通过建立关节盘前移位实验动物模型的方法，来研究人类关节盘前移位病变早期阶段的发展过程和病理学改变。方法１２只新西兰大白兔左颞下颌关节经实验诱导为关节盘前移位模型，右侧为手术对照组。于术后２４ｈ、１周、２周、３周、４周、１０周各处死２只，切取关节组织，ＨＥ染色，光镜观察。结果早期：关节结节、髁突关节软骨增生明显，髁突软骨下出血，骨组织内血管网消失；后期：髁突关节软骨、骨组织及滑膜出现骨关节炎（ＯＡ）样改变。结论实验诱导关节盘前移后关节区的病理学变化与人类相似；关节盘前移位关节区的创伤可引起关节骨关节炎样改变。

Histopathological changes in rabbit TMJ associated with experimentally induced anterior disk displacement

Objective The purpose of this experiment was to investigate the early histopathological changes that occur in the rabbit temporomandibular joint(TMJ) following surgical induction of ADD. Methods The left joints of 12 New Zealand rabbits were subjected to surgical induction of ADD,the right served as sham control.Four joints from two additional rabbits served as nonoperated control.The TMJ were removed after 24h,1 week,2 weeks,3 weeks,4 weeks or 10 weeks and stained with HE. Results The results showed neovascularization,cell clustering and fibrillation of the displaced disk.Fibrosis and pseudodisk formation were observed in bilaminar zone.The condyle and synovial membrane showed osteoarthritic changes. Conclusion Surgical induction of ADD in the rabbit TMJ leads to histopathological changes in TMJ region similar to those described in human ADD,and the mechanical trauma resulting from ADD could lead to the changes in affected joints similar to those described for osteoarthritis.