| 反相高效液相色谱法测定奥扎格雷的含量 |
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| 引用本文： | 翁升.反相高效液相色谱法测定奥扎格雷的含量[J].右江民族医学院学报,2008,30(4):538-539. |
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| 作者姓名： | 翁升 |
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| 作者单位： | 广西钦州市第一人民医院药剂科,广西,钦州,535000 |
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| 摘 要： | 目的建立反相高效液相色谱法测定奥扎格雷的含量。方法采用Kromasil C18(4.6mm×150mm,5μm)色谱柱以0.025mol/L磷酸二氢钾(pH 3.4)-乙腈(85∶15)为流动相,流速为1.0ml/min,以左羟丙哌嗪为内标物,检测波长为274nm。结果奥扎格雷的回归方程Y=0.0023X+0.0165(r=0.9997),其线性范围为4.16~416μg/ml,平均回收率为99.97%(RSD值为0.44%)。结论本法可用于奥扎格雷的含量测定,操作简便,结果准确。
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| 关 键 词： | 反相高效液相色谱法 奥扎格雷 含量测定 |
RP-HPLC in quantitative determination of ozagrel in ozagrel tablets |
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| WENG Sheng.RP-HPLC in quantitative determination of ozagrel in ozagrel tablets[J].Journal of Youjiang Medical College For Nationalities,2008,30(4):538-539. |
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| Authors: | WENG Sheng |
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| Institution: | WENG Sheng (Department of Pharmacy,The First People\'s Hospital of Qinzhou,Qinzhou,Guangxi 535000,China) |
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| Abstract: | Objective To develop a RP- HPLC procedure in determination the quantity of ozagrel. Methods HPLC was carried out using a Kromasil CI8 column （4.6mm×150mm, 5μm） with 0. 025mol/L Potassium dihydrogen phosphate（pH3.4）- acetonitrile （85：15） as the mobile phase, the flow rate was 1.0ml/min, the internal standard was levodropropzine. The UV wavelength was 274nm. Results The regression equation was Y = 0. 0023X ＋ 0. 0165 （ r =0. 9997）. The linear ranged from 4. 16 to 416μg/ml. The mean recovery was 99.97% and RSD was 0.44 %. Key words： Conclusion The proposed method is simple, selective accurate and precise. |
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| Keywords: | reversed-phase high performance chromatography ozagrel quantity determination |
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