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| p53和EGFr在皮肤鳞癌中表达的研究 | |
| 引用本文： | 冯新,王建力,陈莉. p53和EGFr在皮肤鳞癌中表达的研究[J]. 南通医学院学报, 2002, 22(4): 395-396,399 |
| 作者姓名： | 冯新 王建力 陈莉 |
| 作者单位： | 1. 江苏省海门市皮肤病防治所,海门,226100 2. 南通医学院附属医院皮肤科 3. 南通医学院病理学教研室 |
| 基金项目： | 江苏省科委资助课题 (NO.Bs993 5 8) |
| 摘 要： | 目的：研究皮肤鳞癌（SSCC）中p53和表皮生长因子受体（EGFr）的表达，探讨其在SSCC多阶段发生中与癌增殖、分化的关系。方法：采用免疫组化(LSAB)方法研究60例SSCC中p53和EGFr的表达。结果:在正常上皮中p53表达缺乏，癌中p53阳性表达率为56.67%(34/60).EGFr表达于整个癌巢中，p53和EGFr表达在癌的不同分化有显著差异，p53和EGFr的表达两者在SSCC中表达呈显著正相关。结论：在SSCC中由免疫组化显示p53和EGFr过表达的癌细胞常是获得了更具增殖、侵袭和间变能力的细胞类型;p53和EGFr过表达是判断SSCC增殖和分化的有意义指标。 |
| 关 键 词： | 表达 皮肤鳞癌 p53基因 表皮生长因子受体 |
| 文章编号： | 1000-2057(2002)04-0395-02 |
THE EXPRESSIONS OF p53 AND EGFR IN RVELATION TO THE DIFFERENTIATION IN SKIN SQUAMOUS CELL CARCINOMA |
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| FENG Xin,WANG Jianli,CHEN Li. THE EXPRESSIONS OF p53 AND EGFR IN RVELATION TO THE DIFFERENTIATION IN SKIN SQUAMOUS CELL CARCINOMA[J]. ACTA Academiae Medicinae Nantong, 2002, 22(4): 395-396,399 | |
| Authors: | FENG Xin WANG Jianli CHEN Li |
| Affiliation: | FENG Xin,1WANG Jianli,2CHEN Li |
| Abstract: | Objective:The aim of this study was to investigate the expression of p53 and EGFr in skin squamous cell carcinoma(SSCC).Method:Sixty cases of SSCC were studied using immunohistochemistry staining method for monoclone antibody p53 and EGFr and compared p53 and EGFr expression relationship.Results:In normal human epidermis p53 protein was absent.In tumors p53 positive ratio was 56.67%(34/60).In lower differentiated tumors,more cells expression p53.EGFr expression diffused through all carcinoma nest.A significant parallel correlation was found between expressions of the p53 and EGFr.Conclusion:Overexpressions of p53 and EGFr may be as SSCC acquired a more aggressive and anaplasia phenotype,p53 and EGFr appeared to be a valuable criterion for the proliferation and differentiation of SSCC. |
| Keywords: | Skin squamous cell carcinoma(SSCC) p53 Epidermal growth factor receptor(EGFr) |
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