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Biological and clinical significance of PARP1 protein expression in breast cancer |
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| Authors: | Green Andrew R. Caracappa Daniela Benhasouna Ahmed A. Alshareeda Alaa Nolan Christopher C. Macmillan R. Douglas Madhusudan Srinivasan Ellis Ian O. Rakha Emad A. |
| Affiliation: | 1. NCIC Clinical Trials Group, Queen’s University, 10 Stuart Street, Kingston, ON, K7L 3N6, Canada 2. NRG Oncology and the Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA, USA 3. NRG Oncology and the Jewish General Hospital, McGill University, Montreal, QC, Canada 4. Sunnybrook Odette Cancer Centre, University of Toronto, Toronto, ON, Canada 5. British Columbia Cancer Agency, Vancouver, BC, Canada 6. NRG Oncology and the Allegheny Cancer Center at Allegheny General Hospital, Pittsburgh, PA, USA 7. Jewish General Hospital, McGill University, Montreal, QC, Canada |
| Abstract: | Breast Cancer Research and Treatment - Poly(ADP-ribose) polymerase-1 (PARP1) is a key facilitator of DNA repair. PARP inhibitors have gained recent attention as promising therapeutic agents for the... |
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