| P16蛋白在胃癌前病变及胃癌中的表达 |
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| 引用本文： | 缪林,赵志泉,金宁,刘政,潘文林,程铁华.P16蛋白在胃癌前病变及胃癌中的表达[J].南京军医学院学报,2001,23(4):230-231. |
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| 作者姓名： | 缪林 赵志泉 金宁 刘政 潘文林 程铁华 |
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| 作者单位： | 1. 南京医科大学第二附属医院消化科,江苏,南京,210011
2. 江苏省人民医院消化科,江苏,南京,210029 |
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| 摘 要： | 目的：研究Ｐ１６蛋白在胃癌前病变（不典型增生及肠化）及胃癌中的表达。方法：采用免疫组织化学方法检测，１０例正常胃黏膜，１５例胃不典型增生，１５例胃黏膜肠化生，３０例胃癌组织中 Ｐ１６蛋白的表达。结果：Ｐ１６蛋白阳性表达正常胃黏膜９０％，不典型增生８６．６７％，肠化８６．６７％，胃癌３６．６７％，胃癌组与正常对照组及胃癌前病变组间差异均有极显著意义（Ｐ＜０．０１）。结论：Ｐ１６蛋白与胃癌发生有关。
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| 关 键 词： | 胃肿瘤 癌前状态 P16蛋白表达 |
| 文章编号： | 1009-1874(2001)04-0230-02 |
| 修稿时间： | 2001年7月5日 |
Expression of P16 protein in precancerosis and gastric carcinoma |
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| MIAO Lin,ZHAO Zhi-quan,JIN Ning,LIU Zheng,PAN Wen-lin,CHENG Tie-hua.Expression of P16 protein in precancerosis and gastric carcinoma[J].Journal of Nanjing Military Medical College,2001,23(4):230-231. |
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| Authors: | MIAO Lin ZHAO Zhi-quan JIN Ning LIU Zheng PAN Wen-lin CHENG Tie-hua |
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| Institution: | MIAO Lin1,ZHAO Zhi-quan2,JIN Ning1,LIU Zheng1,PAN Wen-lin1,CHENG Tie-hua4 |
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| Abstract: | Objective: To investigate the expression of P16 protein in premalignant lesions and gastric carcinoma, including dysplastic gastric mucosa and intestinal metaplasia in gastric mucosa. Methods:The expression of P16 proteins were measured by SP immunohistochemical method in normal gastric mucosa (10 specimens), dysplastic gastric mucosa (15 specimens), intestinal metaplasia in gastric mucosa (15 specimens), gastric carcinomas (30 specimens). Results:The positive expression of P16 protein was 90% in normal gastric mucosa, 86. 67% in dysplastic gastric mucosa, 86.67% in intestinal metaplasia, 36.67% in gastric carcinoma. There were significant differences between gastic carcinoma group and the normal control group or the precancerous group (P <0. 01). Conclusion: P16 protein is associated with the occurrence of gastric carcinoma. |
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| Keywords: | carcinomas gastric precancerous conditions P16 protein expression |
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