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骨组织工程基因治疗在颅颌面重建中的应用
引用本文:胡镜宙,张志愿. 骨组织工程基因治疗在颅颌面重建中的应用[J]. 中国口腔颌面外科杂志, 2006, 4(2): 143-147
作者姓名:胡镜宙  张志愿
作者单位:1. 上海交通大学医学院附属第九人民医院·口腔医学院,口腔颌面外科
2. 上海市口腔医学研究所,上海市口腔医学重点实验室,上海,200011
摘    要:骨组织工程中直接添加生长因子的方法存在着诸多不足,基因治疗和组织工程技术的结合,为克服这一难题提供了新的方向。本文回顾骨组织工程基因治疗的原理和特点,介绍了脂肪细胞作为骨组织工程靶细胞的研究现状,以及一种大动物模型报告基因的应用;并就颅颌面骨组织工程基因治疗中两种新的组织特异性成骨基因作一综述。

关 键 词:组织工程  基因治疗  脂肪源干细胞  报告基因
文章编号:1672-3244(2006)02-0143-05
收稿时间:2005-12-14
修稿时间:2006-01-24

Appication of bone tissue engineering using gene therapy in the repair of craniofacial bone defects
HU Jing-zhou,ZHANG Zhi-yuan. Appication of bone tissue engineering using gene therapy in the repair of craniofacial bone defects[J]. China Journal of Oral and Maxillofacial Surgery, 2006, 4(2): 143-147
Authors:HU Jing-zhou  ZHANG Zhi-yuan
Abstract:Summary The protein- based therapies used in tissue engineering are not optimal due to their inherent shortages that retard their applications. The use of gene therapy in bone tissue engineering offers alternative strategies for the repair of bone defects. This review focused on recent advances in the use of adipose- derived stromal cells (ADSCs) and a report gene in a large animal model. Two types of gene are presented which, as had been demonstrated to be of tissue- specific and bone formation- related, can be used as new bone growth factors, especially for the repair of craniofacial bone defects.
Keywords:Tissue engineering  Gene therapy  Adipose- derived stromal cells  Report gene
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