131I治疗甲亢后早发甲减的多因素分析

为了解131I治疗甲亢后早发甲减的影响因素,对接受131I治疗的120例甲亢患者在1年内跟踪随访,对可能与早发甲减有关的多个因素用二项分类Logistic进行了回归分析.结果显示:①每克甲状腺组织给予131I平均剂量,回归系数为正值,为危险因素;甲状腺的质量的回归系数为负值,为保护因素;②对研究对象进行Logistic回归判别,早发甲减与不发甲减的准确率分别为53.3%及96.1%,总准确率为46.7%.结论为131I治疗甲亢后早发甲减可能受多种因素影响,在治疗前主要根据甲状腺的质量适当调整剂量,可一定程度减少早发甲减的发生率.

Analysis of Factors for Early Hypothyroidism after 131I Treatment of Hyperthyroidism

To explore the factors for the early hypothyroidism following ~(131)I treatment of hyperthyroidism,clinic data of 120 hyperthyroidism patients including 8 independent and 1 dependent variables after one year ~(131)I treatment were analyzed by logistic regression analysis method.The results showed that the average ~(131)I dosage given to one gram thyroid tissue was correlated positively with early hypothyroidism occurrence,and the weight of thyroid was negatively correlated to early hypothyroidism occurrence.The positive and negative prediction accuracy of the early hypothyroidism were 53.3% and 96.1% respectively,and the total prediction accuracy was 46.7%.The results suggest that the ~(131)I dosage and the weight of thyroid are key factors for early hypothyroidism;the appropriate adjustment of ~(131)I dosage based on the thyroid mass could prevent the early hypothyroidism occurrence in certain degree.