脑梗死急性期血清中神经元特异性烯醇化酶水平的变化及其临床意义

目的探讨脑梗死患者急性期血清中神经元特异性烯醇化酶(NSE)水平的变化及临床意义。方法采用ELISA法测定了56例脑梗死患者急性期和30例性别、年龄结构相匹配的健康人血清中NSE水平,应用CT扫描测定脑梗死体积和斯堪的那维亚卒中量表(SNSS)进行神经功能缺损评分。结果脑梗死患者急性期血清中NSE水平显著高于对照组(P<0.01),血清中NSE水平与脑梗死面积和神经功能缺失程度呈显著正相关(P<0.05)。结论脑梗死患者急性期血清中NSE水平增高与神经元坏死有关,NSE水平的高低可以反映脑梗死面积的大小,为脑梗死后神经元损伤程度提供定量信息。

Measurement of serum neuron specific enolase and its clinical value in patients with acute cerebral infarction

Objective To explore the level of serum neuron specific enolase(NSE) and its clinical significance in patients with acute cerebral infarction.Methods Serum NSE level was measured using ELISA methods in 56 patients with acute cerebral infarction and 30 healthy controls matched in sex and age,cerebral infarction volume was determined by CT and clinical neurologic function impairment score was evaluated by Scandinavian Neurological Stroke Scale(SNSS).Results Serum NSE level was significantly higher in patients after acute cerebral infarction than control(P<0.01).There was a significant positive correlation among serum NSE and cerebral infarction volume and neurologic function impairment degree(P<0.05).Conclusion Increased serum NSE level is related with neuron necrosis in acute cerebral infarction patients.Serum NSE level may reflect cerebral infarction size,and provide quantitative information for neuron damage degree after cerebral infarction.