通心络胶囊治疗原发性高血压临床疗效及其对血液流变学的影响

目的观察通心络胶囊治疗高血压痰瘀交互、脉络瘀阻或气虚血瘀络阻证的临床疗效，及其对血液流变学的影响。方法选择中医辨证为痰瘀交互、脉络瘀阻或气虚血瘀络阻证，经血液流变学检测确诊异常的高血压患者147例，随机分为治疗组74例和对照组73例。2组均给予常规降压、降脂、生活干预等治疗，治疗组在此基础上服通心络胶囊，每次4粒，每日3次。12周为1个疗程。观察2组治疗前后症状积分、血压、血脂、血液流变学变化及临床疗效。结果2组治疗前后血液流变学指标及血脂组内比较，P〈0．05。治疗后2组间比较，P〈0．05。2组间总疗效、血压控制情况比较，P〈0．05，治疗组优于对照组。中医症状改善率治疗组明显优于对照组。结论加用通心络胶囊对高血压患者的血液流变学多项指标有影响，且能改善患者的临床症状，并且无明显不良反应。

Clinical Efficacy of Tongxinluo Capsule in Patients with Essential Hypertension and Its Effect on Hemorheology

Objective To observe the clinical efficacy of Tongxinluo Capsule on hypertension with interaction of phlegm and blood stasis, context stagnation or Qi deficiency and blood stasis, and its impact on blood theology. Methods One hundred and forty-seven cases of hypertension were randomly divided into treatment group （74 cases） and control group （73 cases）. Both groups were given conventional antihypertensive and lipid-lowering treatment, and the treatment group was given Tongxinluo Capsule additionally. Symptom score, blood pressure, lipid and rheology of two groups were observed before and after treatment. Results There was no significant difference between before and after treatment in hemorheology and blood lipid of two groups （P〈0.05）. The clinical efficacy and control effect of blood pressure in the treatment group were superior than the control group （P〈0.05）. Improvement rate of symptoms in the treatment group was superior than the control group （P 〈0.05）. Conclusions Tongxinluo Capsule has effect on hemorheology indicators, can improve the clinical symptoms of hypertension patients, and has no significant side effects.