新一代非甾体药物——溴芬酸钠在屈光手术的应用及注意事项

准分子激光角膜屈光手术矫治屈光不正的有效性和安全性已得到广泛的认同,而围手术期药物的有效、合理应用,也使得手术者对手术的满意度大大提高.眼局部糖皮质激素的应用是准分子激光角膜屈光手术不可缺少的,但是糖皮质激素应用后的不良反应和并发症时有发生,特别是应用时间较长的患者.近几年非甾体抗炎药(NSAIDs)在眼科的应用逐渐广泛,其中溴芬酸钠是环氧化酶-2的抑制剂,眼部用药效果好,不良反应少,与小剂量糖皮质激素的作用相当,但其在角膜屈光手术中能否起到与糖皮质激素同样的效果值得研究.

Application and notice of a new generation of non-steroidal eye drops in refractive surgery

The efficacy and safety of excimer laser corneal refractive surgery for refractive error correction have been widely recognized, and effective and appropriate application of perioperative medication also greatly improved patients＇ satisfaction with surgery. Topical application of glucocorticoid is indispensable for the excimer laser corneal refractive surgery, and it can not be replaced by any other medication for more than 20 years. However, adverse reactions and complications after the application of glucocorticoid are not rare,especially in patients who are long-term users. Therefore, in recent years, non-steroidal anti-inflammatory drugs are becoming more widely used in ophthalmology. Bromfenac sodium, an inhibitor of cyclooxygenase-2, could assume the role as low-concentration glucocorticoids with good medical effects and less adverse effects. But whether it could attain the same therapeutic effects as glucocorticoids in corneal refractive surgery is a subject worth studying.