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| ERCC1、XPD和BRCA1基因多态与晚期非小细胞肺癌患者铂类药物化疗效果的相关性 | |
| 引用本文： | 苏彤,赵立军,常文军,王国萍,何永超,孙沁莹,张宏伟,李强,曹广文. ERCC1、XPD和BRCA1基因多态与晚期非小细胞肺癌患者铂类药物化疗效果的相关性[J]. 第二军医大学学报, 2010, 31(2): 117-122. DOI: 10.3724/SP.J.1008.2010.00117 |
| 作者姓名： | 苏彤 赵立军 常文军 王国萍 何永超 孙沁莹 张宏伟 李强 曹广文 |
| 作者单位： | 1. 第二军医大学基础部流行病学教研室,上海,200433 2. 第二军医大学长海医院呼吸内科,上海,200433 |
| 基金项目： | 上海市登山计划重大课题(06DZ19503)~~ |
| 摘 要： | 目的探讨核苷酸切除修复系统(NER)的3个重要基因切除修复交叉互补基因1(ERCC1)、着色性干皮病基因D(XPD)和乳腺癌易感基因1(BRCA1)的单核苷酸多态性(SNPs)与晚期非小细胞肺癌(NSCLC)患者铂类药物化疗效果的相关性。方法对124例接受含铂类药物化疗的晚期NSCLC患者进行临床疗效评价。采用TaqMan探针法对ERCC1Asn118Asn(rs11615)、XPD Lys751Gln(rs13181)和BRCA1 Ser1613Gly(rs1799966)进行基因型分析。比较不同基因型与铂类药物化疗效果的关系。结果BRCA1 Ser1613Gly遗传多态与铂类药物化疗临床受益显著相关(P=0.014),携带Gly等位基因的患者临床受益率明显高于野生型患者(P=0.006)。没有发现ERCC1 Asn118Asn和XPD Lys751Gln与临床受益的相关性。这3个基因多态存在一定联合作用,携带变异等位基因(ERCC1 T,XPD Gln和BRCA1 Gly)的数目越多,化疗临床受益率越高(P=0.036)。结论NER系统中的BRCA1 Ser1613Gly遗传多态与晚期NSCLC患者铂类药... |
| 关 键 词： | 单核苷酸多态性 ERCC1 XPD BRCA1 非小细胞肺癌 化疗 |
| 收稿时间： | 2009-09-01 |
| 修稿时间： | 2009-12-03 |
Relationship of ERCC1,XPD,and BRCA1 polymorphisms with efficacy of platinum-based chemotherapy for patients with advanced non-small cell lung cancer |
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| SU Tong,ZHAO Li-jun,CHANG Wen-jun,WANG Guo-ping,HE Yong-chao,SUN Qin-ying,ZHANG Hong-wei,LI Qiang,CAO Guang-wen. Relationship of ERCC1,XPD,and BRCA1 polymorphisms with efficacy of platinum-based chemotherapy for patients with advanced non-small cell lung cancer[J]. Former Academic Journal of Second Military Medical University, 2010, 31(2): 117-122. DOI: 10.3724/SP.J.1008.2010.00117 | |
| Authors: | SU Tong ZHAO Li-jun CHANG Wen-jun WANG Guo-ping HE Yong-chao SUN Qin-ying ZHANG Hong-wei LI Qiang CAO Guang-wen |
| Affiliation: | 1. Department of Epidemiology, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China;2. Department of Respiratory Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China |
| Abstract: | Objective To investigate the relationship of excision repair cross-complementing 1(ERCC1),xeroderma pigmentosum group D(XPD),and breast cancer susceptibility gene 1(BRCA1) polymorphisms with the efficacy of platinum-based chemotherapy for treatment of the patients with advanced non-small cell lung cancer.Methods A total of 124 patients with advanced NSCLC were routinely treated with platinum-based chemotherapy,and their clinical responses were evaluated.ERCC1 Asn118Asn(rs11615),XPD Lys751Gln(rs13181) and BR... |
| Keywords: | single nucleotide polymorphism ERCC1 XPD BRCA1 non-small-cell lung cancer chemotherapy |
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