Stair climbing ability in patients with early knee osteoarthritis: Defining the clinical hallmarks of early disease |
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| Institution: | 1. Department of System Design Engineering, Faculty of Science and Technology, Keio University, Yokohama, Japan;2. Department of Physical Therapy, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan;3. Japan Society for the Promotion of Science, Tokyo, Japan;4. Department of Physical Medicine and Rehabilitation, University of Pittsburgh, United States;5. McGowan Institute for Regenerative Medicine, University of Pittsburgh, United States;6. School of Science for Open and Environmental Systems, Graduate School of Science and Technology, Keio University, Yokohama, Japan;1. Gait & Motion Analysis Laboratory, Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong;2. Movement Laboratory, Health Department, Bern University of Applied Sciences, Switzerland;1. School of Health & Rehabilitation Sciences, The University of Queensland, St Lucia, Queensland 4072, Australia;2. La Trobe Sport and Exercise Medicine Research Centre, College of Science, Health and Engineering, La Trobe University, Bundoora, Victoria 3086, Australia;3. School of Biomedical Sciences, The University of Queensland, St Lucia, Queensland, 4072, Australia;1. Wolf Orthopaedic Biomechanics Laboratory, Fowler Kennedy Sport Medicine Clinic, University of Western Ontario, London, ON N6A 3K7, Canada;2. School of Physical Therapy, Faculty of Health Sciences, University of Western Ontario, London, ON N6G 1H1, Canada;3. Bone and Joint Institute, University of Western Ontario, London Health Sciences Centre - University Hospital, London, ON N6A 5B5, Canada;4. Department of Surgery, Schulich School of Medicine and Dentistry, University of Western Ontario, St. Joseph''s Health Care London, London, ON N6A 4V2, Canada;1. Department of Orthopaedics and Traumatology, University Hospital Basel, Basel, Switzerland;2. Department of Clinical Research, University of Basel, Basel, Switzerland;3. Department of Biomedical Engineering, University of Basel, Basel, Switzerland;4. Institute of Physiotherapy, Zurich University of Applied Sciences, Winterthur, Switzerland;5. CLARAHOF Clinic of Orthopaedic Surgery, Clarahofweg 19a, 4058 Basel, Switzerland;6. Clinic for Orthopaedics Claraortho, Claragraben 82, 4058 Basel, Switzerland;7. ENDO-Team Hirslanden Klinik Birshof, Reinacherstrasse 28, 4142 Münchenstein, Switzerland;8. Department of Spine Surgery, University Hospital Basel, Basel, Switzerland;1. Department of Kinesiology, KU Leuven, Belgium;2. Department of Mechanical Engineering, KU Leuven, Belgium;3. School of Healthcare Science, Manchester Metropolitan University, United Kingdom;4. Department of Rehabilitation Sciences, KU Leuven, Belgium;5. School of Sport and Exercise Sciences, Liverpool John Moores University, United Kingdom;6. Department of Development and Regeneration, KU Leuven, Belgium;1. Department of Orthopaedic Surgery, CAPHRI School for Public Health and Primary Care, Maastricht University Medical Center, P.O. Box 5800, 6202 AZ, Maastricht, the Netherlands;2. Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, P.O. Box 616, 6200 MD, Maastricht, the Netherlands |
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| Abstract: | BackgroundA growing clinical interest has been shown towards identifying knee osteoarthritis (OA) patients at earlier stages. The early detection of knee OA may allow for more effective interventions.Research questionThe aim of this study was to determine the discriminative ability of a stair-climb test (SCT) in identifying patients with early knee OA, and to determine if descending stair time during the SCT is better than ascending stair time for the identification of these patients.MethodsThis study was a secondary, cross-sectional analysis of baseline data from a randomized controlled trial. Adults with moderate to severe knee pain were enrolled (n = 57; mean age 58.9 years; 71.9% women). Each participant performed an 11-step SCT (11-SCT) while wearing shoes with a pressure sensor insole. A receiver operating characteristic analysis was used to examine the discriminative power of 11-SCT for identifying early knee OA (Kellgren and Lawrence grade 1). The discriminative power was also compared between the ascending and descending 11-SCT time as evaluated by the pressure sensor.ResultsThe 11-SCT time in patients with early knee OA was 0.55 s longer than that in those with symptomatic non-radiographic OA. A one-second increase in the 11-SCT time was significantly associated with 1.9-fold increased odds of early knee OA being present. The 11-SCT value with the best balance of sensitivity and specificity for identifying early knee OA was 8.33 s (area under the curve: 0.711). The descending time was not significantly better than the ascending time for identifying early knee OA.SignificanceThis study determined the time values of an 11-SCT that may be useful for identifying early knee OA patients. These preliminary findings may serve as the foundation for future studies investigating the clinical hallmarks associated with early knee OA. |
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| Keywords: | Early knee osteoarthritis Stair climb test Receiver operating characteristic |
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