北京市首都钢铁公司男工冠心病危险因素前瞻性研究——血压、血清总胆固醇及吸烟与冠心病关系

本文用Cox回归分析首都钢铁公司5 298名男工随访8.38年冠心病发病及其危险因素的研究结果,得出冠心病发病和死亡率随血压和血清总胆固醇水平升高而增加;在胆固醇浓度>5.3mmol/L(200mg/dl)情况下,冠心病危险还随每日吸烟支数增加而增加。

A PROSPECTIVE STUDY ON RISK FACTORS OF CORONARY HEART DISEASE AMONG MALE WORKERS IN CAPITAL IRON AND STEEL COMPANY: THE RELATIONSHIP BETWEEN BLOOD PRESSURE, CHOLESTEROL AND SMOKING WITH CHD

A baseline survey on risk factors of CHD was performed among 5298 male workers over 18 years of age. Within a 8.38 years follow-up period(42909 person year)27 cases of acute myocardial infarction and 14 sudden coronary death were found, the incidence rates were 63/100,000 and 33/100,000 respectively with mortality rate of 16/100,000 and 33/100,000 respectively. Cox regression and relative risk analysis on the main risk factors of CHD showed that: 1. Blood pressure (BP): Both systolic and diastolic BP remained significantly related to CHD. In borderline and definite hypertension group the incidence of CHD were 1.2 and 3.6 times higher than that of normotensive group. Even in subjects with higher-normal BP(120-139/80-89mmHg) had a higher incidence by 40-50% than those with lower-normal (<120/80mmHg). 2. Serum total cholesterol (TC): The incidence and mortality rate of CHD were found to be generally higher with increased serum total cholesterol. The TC>240mg/dl group had higher CHD incidence than TC=200-239mg/dl (1.9 times) and <200mg/dl group (3.2 times). The group with both TC>240mg/dl and definite hypertension had the highest (11.3 times)incidence of CHD than normotensive and normal TC group. 3. Serum cholesterol level and smoking: Among those persons with TC>200mg the incidence of CHD increased parallelly with the number of cigarettes smoked per day.