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| 氟伏沙明的合成工艺改进 | |
| 引用本文： | 刘滔,盛荣,胡永洲. 氟伏沙明的合成工艺改进[J]. 浙江大学学报(医学版), 2003, 32(5): 441-442 |
| 作者姓名： | 刘滔 盛荣 胡永洲 |
| 作者单位： | 浙江大学药学院,浙江,杭州,310031 |
| 摘 要： | 目的：改进氟伏沙明的合成方法。方法：以对三氟甲基苯甲腈为原料，经格氏反应和水解制成5-甲氧基-4’-三氟甲基苯基戊酮，再经肟化制成5-甲氧基-4'-三氟甲基-O-(2-胺乙基)戊酮肟，最后与马来酸成盐制得氟伏沙明。结果：合成产物总收率达36．1%，其结构经核磁共振谱确证。结论：此改进的合成路线是可行的。 |
| 关 键 词： | 氟伏沙明 化学合成 |
| 文章编号： | 1008-9292(2003)05-0441-02 |
| 修稿时间： | 2001-07-11 |
Improved method of fluvoxamine synthesis |
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| LIU Tao,SHENG Rong,HU Yong-zhou. Improved method of fluvoxamine synthesis[J]. Journal of Zhejiang University. Medical sciences, 2003, 32(5): 441-442 | |
| Authors: | LIU Tao SHENG Rong HU Yong-zhou |
| Affiliation: | College of Pharmaceutical Sciences Zhejiang University, Hangzhou 310031 China. |
| Abstract: | Objective: To modify the synthetic method of fluvoxamine. Methods: Fluvoxamine was synthesized from 4-trifluoromethylbenzonitrile by the steps of Grignard reaction, hydrolysis and oximation. Results: The chemical structure of the synthesized product was confirmed by 1HNMR, and the total yield reached to 36.16%. Conclusion: The results indicate that the synthetic route is practical. |
| Keywords: | Fluvoxamine/chem syn |
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