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IMPAIRED DELAYED HYPERSENSITIVITY IN SUBACUTE SCLEROSING PANENCEPHALITIS |
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| Authors: | A. KLAJMAN MARION STERNBACH LOTTE RANON M. DRUCKER D. GEMINDER N. SADAN |
| Affiliation: | Immunological Laboratory, Meir Hospital, Kfar Saba, Tel-Aviv University Medical School, the Virus Laboratory, Ministry of Health, Tel-Aviv, and the Department of Paediatrics, Meir Hospital, Kfar Saba, Israel |
| Abstract: | Two children with subacute sclerosing pan-encephalitis showed impaired delayed hypersensitive reaction to killed measles virus in the presence of normal response to candida extract, phytohemagglutinin and PPD. These results suggest that the persistence of the virus in the brain may induce tolerance of the T lymphocytes to it and perpetuate the disease. |
| Keywords: | Subacute sclerosing panencephalitis (SSPE) measles delayed hypersensitivity |