人参皂苷CK对四氯化碳致大鼠慢性肝损伤的影响

目的研究人参皂苷CK对CC l4致慢性肝损伤的影响。方法用CC l4致大鼠慢性肝损伤模型,观察人参皂苷CK(0.3,1,3 mg/kg)对大鼠血清天冬氨酸转氨酶(aspartate transam inase,ALT)、丙氨酸转氨酶(alan ine transam inase,AST)、超氧化物歧化酶(superoxide d ismutase,SOD)、丙二醛(m alond ialdehyde,MDA)及透明质酸(hyaluron ic ac id,HA)、Ⅲ型前胶原(pre-collagenⅢ,PCⅢ)的影响,并对肝脏组织进行病理学观察。结果人参皂苷CK小剂量(0.3 mg/kg)能降低血清转氨酶ALT,AST水平,增加血清SOD的含量,降低MDA含量;CK中、高剂量无明显作用。CK各剂量组血清HA、PCⅢ和肝组织病理未见明显改变。结论CK低剂量对CC l4致慢性肝损伤具有一定的保护作用,其作用可能与抗氧化有关。

Effect of Compound K on Chronic Hepatic Injury Induced by Carbon Tetrachloride (CCl_4) in Rats

ObjectiveTo observe the effect of Compound K on chronic hepatic injury induced by CCl_4 in rats.MethodsIn male Wistar rats hepatic chronic injury was induced by the subcutaneous administration of CCl_4 twice a week for six weeks.Then rats were given Compound K at dose of 0.3,1 or 3 mg/kg respectively for a further four weeks.At the end the biochemical parameters associated with hepatic injury were determined,and the histopathology of liver was observed.ResultsCompared with the model group,activities of alanine aminotransferase(ALT), aspartate aminotransferase(AST) were significantly reduced by Compound K at dose of 0.3 mg/kg,accompanied with that the amount of superoxide dismutase(SOD) markedly increased and malondialdehyde(MDA) reduced obviously,while no significant changes in the amount of hyaluronic acid(HA) and procollagen III(PCIII) or histopathology were observed.ConclusionCompound K at low dose could protect liver from injury induced by CCl_4,which may be associated with its antioxidation effect.