基于QLICP-CE（V2.0）量表的宫颈癌患者生命质量及其与临床客观指标的典型相关分析

目的 分析宫颈癌患者生命质量与临床客观指标之间的关系。方法 采用癌症患者生命质量测定量表体系之宫颈癌量表（QLICP-CEV2.0）对186名宫颈癌患者进行调查，采用典型相关分析来研究生命质量得分与其临床客观指标之间的关系。结果 乳腺癌患者生命质量标准得分分别为:总量表（59.97±14.27），躯体功能领域（55.01±14.85），心理功能领域（55.55±16.61），社会功能领域（60.32±14.63），共性症状与副作用领域（64.76±21.03），特异模块领域（63.87±24.48）。典型相关分析显示有5对典型变量，其典型相关系数分别为r1=0.419、r2=0.401、r3=0.332、r4=0.292、r5=0.206，前四对P<0.05，前两对典型变量可解释60.742%的信息量。结论 铁、丙氨酸氨基转移酶、天门冬氨酸氨基转移酶/丙氨酸氨基转移酶、乳酸脱氢酶、中性粒细胞百分率、淋巴细胞百分率、单核细胞百分率、白/球蛋白与患者的生命质量具有较高的相关性，临床医生治疗时应予以重视，并综合多方面因素提高宫颈癌患者的生命质量。

Quality of life in patients with cervical cancer and their clinical objective indicators based on QLICP-CE(2.0): a canonical correlation analysis

To analyze the relationship between the quality of life in patients with cervical cancer and the clinicalobjective indicators. Methods A total of 186 patients with cervical cancer were investigated using the Quality of LifeInstrument for Cancer Patients － Cervical Cancer ( QLICP － CEV2. 0) ，and the data were used to analyze the relationships ofthe clinical objective indicators with the QOL scores by canonical correlation analysis. Ｒesults The standardized scores ofquality of life in patients with cervical cancer were 59. 97 ± 14. 27 for the overall scale，and 55. 01 ± 14. 85，55. 55 ± 16. 61，60. 32 ± 14. 63，64. 76 ± 21. 03，63. 87 ± 24. 48 for domains of physical function，psychological function，social function，common symptoms and side effects and the specific module，respectively. Five pairs of canonical variables were obtainedthrough canonical correlation analysis，and the canonical coefficients were r1 = 0. 419，r2 = 0. 401，r3 = 0. 332，r4 = 0. 292，r5= 0. 206 with the first four pairs P ＜ 0. 05. The two pairs of canonical variables could explain 60. 742% of the amount ofinformation( Variance) . ConclusionThe levels of Fe，ALT，AST/ALT，LDH，LYMPHＲ，NEUTＲ，MONOＲ，A/G are stronglycorrelated with quality of life，to which clinicians should pay more attention in the treatment. And comprehensive factors shouldbe considered to improve the quality of life in patients with cervical cancer.