中山市高尿酸血症的流行概况及其危险因素分析

目的 分析中山市高尿酸血症的流行情况以及其危险因素，并进一步探讨预测高尿酸血症发生的可能的指标因素。方法 于2016年在广东省中山市应用多阶段随机抽样的方法进行现况调查，实际抽取7 174名居民进行问卷调查、体格检查及实验室检测，并采用多因素logistic回归分析各影响因素。结果 中山市总体高尿酸血症患病率为31.91%。多因素logistic回归分析表明，男性(OR = 1.783, 95%CI :1.544～2.059)、偶尔饮酒(OR = 1.198, 95%CI :1.030～1.394)、经常饮酒(OR = 1.388, 95%CI:1.186～1.623)、患高胆固醇血症(OR = 1.267, 95%CI :1.054～1.521)、超重/肥胖(OR = 1.901, 95%CI :1.657～2.181)、患中心性肥胖(OR = 1.311, 95%CI :1.139～1.509)、血压高(OR = 1.321, 95%CI :1.170～1.491)、空腹TG含量≥1.7 mmol/L(OR = 2.016, 95%CI:1.772～2.295)、空腹HDL - C含量＜1.0mmol/L(OR = 1.439, 95%CI: 1.088 ～1.903)等是中山市常住居民患高尿酸血症的独立危险因素。结论 中山市成年居民高尿酸血症患病率已经达到较高水平，应对其危险因素进行干预，减少中山市高尿酸血症发生的风险。

Analysis of prevalence and risk factors of hyperuricemia in Zhongshan

The aim of this study was to analyze the prevalence, risk factors of hyperuricemia and explore the indexfor predicting the occurrence of hyperuricemia in Zhongshan. Methods In 2016, we adopted a multi-stage random samplingmethod in Zhongshan city, Guangdong province, and selected 7174 residents for questionnaire surveys, physical examinationsand laboratory inspections. Multivariate logistic regression analysis was used to analyze these data. Results The overallprevalence of hyperuricemia in Zhongshan city was 31.91%. Multivariate logistic regression analysis showed that men (OR=1.783, 95% CI: 1.544-2.059), occasional alcohol consumption (OR=1.198, 95% CI: 1.030-1.394), regular drinking (OR=1.388,95% CI: 1.186-1.623), hypercholesterolemia (OR=1.267, 95% CI: 1.054-1.521), overweight/obesity (OR=1.901, 95% CI: 1.657-2.181), central obesity (OR=1.311, 95% CI: 1.139-1.509), hypertension (OR=1.321, 95% CI: 1.170-1.491), fasting TG content≥1.7mmol/L (OR=2.016, 95% CI: 1.772-2.295) and fasting HDL-C content <1.0mmol/L (OR=1.439, 95% CI: 1.088-1.903) wereindependent risk factors for hyperuricemia among resident residents in Zhongshan city. Conclusion The prevalence ofhyperuricemia in adult residents of Zhongshan city reached a high level. Risk factors should be intervened to reduce the riskof hyperuricemia in Zhongshan city