糖尿病家族史和超重/肥胖的交互作用对育龄女性高血糖的影响

目的 探讨糖尿病家族史和超重/肥胖对育龄女性高血糖的交互作用。方法 将2013-2018年参加深圳市孕前优生健康检查的199037例育龄女性作为研究对象，收集基本人口学特征、糖尿病家族史、身高、体重、空腹血糖、血压等信息，采用非条件logistic回归分析糖尿病家族史、超重/肥胖对育龄女性高血糖的影响，使用相加模型评价二者对高血糖的交互作用。结果 育龄女性中高血糖者占4.20%，糖尿病家族史者占6.78%，超重/肥胖者占14.88%。logistic回归分析结果显示，糖尿病家族史、超重/肥胖为育龄女性高血糖的危险因素，OR分别为1.208（95% CI:1.115~1.307）和1.915（95% CI:1.809~2.026）。相加模型分析结果显示，糖尿病家族史与超重/肥胖对育龄女性高血糖存在协同作用（RERI=0.519，95% CI:0.133~0.904；AP=0.207，95% CI:0.080~0.334；SI=1.525，95% CI:1.154~2.015）。结论 糖尿病家族史和超重/肥胖对育龄女性高血糖存在协同作用。

Interaction between family history of diabetes and overweight/obesity on hyperglycemia among reproductive-age females

Objective To explore the interaction between family history of diabetes and overweight/obesity on hyperglycemia among reproductive-age females. Methods A total of 199037 reproductive-age females who participated in the Preconception Checkup Projects in Shenzhen from 2013 to 2018 were selected as the research objects. Basic demographic characteristics, family history of diabetes, height, weight, fasting blood glucose, blood pressure and other information were collected. The effects of family history of diabetes and overweight/obesity on hyperglycemia among reproductive-age females were analyzed by non-conditional logistic regression model, and the interaction between the two on hyperglycemia was evaluated by the additive model. Results Among reproductive-age females, 4.20% had hyperglycemia, and 6.78% had diabetes family history, and 14.88% of which were overweight or obesity. Multivariate logistic regression analysis showed that family history of diabetes and overweight/obesity were risk factors for hyperglycemia among reproductive-age females, with OR of 1.208(95%CI:1.115～1.307) and 1.915(95%CI:1.809～2.026), respectively. The additive model analysis results showed that family history of diabetes and overweight/obesity had a synergistic effect on hyperglycemia among reproductive-age females(RERI=0.519, 95%CI:0.133～0.904; AP=0.207, 95%CI:0.080～0.334; SI=1.525, 95%CI:1.154～2.015). Conclusion Family history of diabetes and overweight/obesity have synergistic effect on hyperglycemia in reproductive-age females.