| 抑癌基因DPC4在胃癌蛋白的表达及临床意义 |
| |
| 引用本文： | 邵云霞,曲延刚,朱文娣. 抑癌基因DPC4在胃癌蛋白的表达及临床意义[J]. 河北医学, 2006, 12(2) |
| |
| 作者姓名： | 邵云霞 曲延刚 朱文娣 |
| |
| 作者单位： | 青岛大学医学院第二附属医院,山东,青岛,266042 |
| |
| 摘 要： | 目的:研究DPC4(SMAD4)蛋白在胃癌的表达及临床意义。方法:应用免疫组化SP法,对40例胃癌及20例癌周粘膜进行检测,并结合临床资料进行研究。结果:胃癌DPC4(SMAD4)蛋白的表达阳性率为75%(30/40),20例癌周粘膜内DPC4(SMAD4)蛋白均呈强阳性表达,两者比较差异有显著性意义(P<0.05)。DPC4蛋白在胃癌的表达与患者年龄、发生部位无关(P>0.05),而与临床分期、淋巴结转移、病理分级、肿物大小有关性(P<0.01)。结论:DPC4(SMAD4)蛋白的表达与胃癌的发生发展密切相关,对预后的判断有参考价值。
|
| 关 键 词： | 胃癌 DPC4基因 免疫组化 |
Expression and Significance of DPC4 in Gastric Cancer |
| |
| SHAO Yun-xia,QU Yan-gang,ZHU Wen-di. Expression and Significance of DPC4 in Gastric Cancer[J]. Hebei Medicine, 2006, 12(2) |
| |
| Authors: | SHAO Yun-xia QU Yan-gang ZHU Wen-di |
| |
| Abstract: | Objective: To investigate the expression of DPC4 in gastric cancer and evaluate its clinical significance.Methods: DPC4 was measured in 80 cases of gastric cancer tissues and 20 cases of benign disease by immunohistochemistry SP method using monoclonal antibody to their protein.Results: The expression of DPC4 in breast cancer was 75%(30/40).There was significantly higher than that in benign disease.Their expression was not related to gender and position of the disease(P>0.05),but related to pathology stage clinical stage,lymph node metastasis and tumor sides(P<0.01).Conclusion: The expression of DPC4 was closely correlated with the gastric cancer and more valuable about predicting. |
| |
| Keywords: | Gastric cancer DPC4 Immunohistochemistry |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
