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| Heparanase-1在恶性嗜铬细胞瘤中的表达及其意义 | |
| 引用本文： | ZHU Yu,吴瑜璇,SHEN Zhoujun,袁菲,ZHANG Jun,芮文斌,ZHANG Congyu,计骏,ZHAO Juping,孙福康,ZHOU Wenlong,谢欣,JIN Xiaolong,宁光.Heparanase-1在恶性嗜铬细胞瘤中的表达及其意义[J].临床泌尿外科杂志,2008,24(6). |
| 作者姓名： | ZHU Yu 吴瑜璇 SHEN Zhoujun 袁菲 ZHANG Jun 芮文斌 ZHANG Congyu 计骏 ZHAO Juping 孙福康 ZHOU Wenlong 谢欣 JIN Xiaolong 宁光 |
| 作者单位： | 1. 上海交通大学医学院附属瑞金医院泌尿外科,上海,200025 2. 上海交通大学医学院附属瑞金医院病理科,上海,200025 3. 上海交通大学医学院附属瑞金医院普外科,上海,200025 4. 上海交通大学医学院附属瑞金医院内分泌代谢科,上海,200025 |
| 摘 要： | 目的:探讨类肝素酶(Heparanase)成为一种预判肾上腺恶性嗜铬细胞瘤指标的可能性.方法:选取经手术治疗且具有完整的临床、病理和随访资料的肾上腺嗜铬细胞瘤患者的存档石蜡标本27例,其中良性嗜铬细胞瘤10例(良性组),恶性嗜铬细胞瘤17例(恶性组).另取5例因良性肾疾患行肾切除时获取的同侧正常肾上腺组织作为对照组.采用免疫组织化学技术检测良、恶性嗜铬细胞瘤及正常肾上腺髓质组织中Heparanase-1的表达情况.结果:Heparanas-l在肾上腺恶性嗜铬细胞瘤中表达最高(76.5%),在肾上腺良性嗜铬细胞瘤中表达较低(30.0%),在正常肾上腺髓质组织中无表达,恶性组与良性组及恶性组与正常组之间Heparanase-1的表达差异有统计学意义(P<0.05).结论:Heparanase-1有望成为预判肾上腺恶性嗜铬细胞瘤的一种指标. |
| 关 键 词： | 嗜铬细胞瘤 肾上腺肿瘤 肿瘤标志物 免疫组织化学 |
Expression of Heparanase-1 in malignant pheochromocytomas |
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| ZHU Yu,WU Yuxuan,SHEN Zhoujun,YUAN Fei,ZHANG Jun,RUI Wenbin,ZHANG Congyu,JI Jun,ZHAO Juping,SUN Fukang,ZHOU Wenlong,XIE Xin,JIN Xiaolong,NING Guang.Expression of Heparanase-1 in malignant pheochromocytomas[J].Journal of Clinical Urology,2008,24(6). | |
| Authors: | ZHU Yu WU Yuxuan SHEN Zhoujun YUAN Fei ZHANG Jun RUI Wenbin ZHANG Congyu JI Jun ZHAO Juping SUN Fukang ZHOU Wenlong XIE Xin JIN Xiaolong NING Guang |
| Abstract: | Objective:To analyse the value of Heparanase-1(HPA) as marker for malignant pheochromocytomas.Methods: 27 paraffin-embedded specimens included 10 benign pheochromocytomas and 17 malignant pheochromocytomas obtained from operations performed in Rui Jin Hospital affiliated to Shanghai Jiao Tong University School of Medicine from 1986 to 2006 with complete clinical,pathological and follow-up records were selected.Ipsilateral normal adrenal glands from 5 cases underwent nephrectomy for benign renal tumors serve... |
| Keywords: | Pheochromocytoma Adrenal tumor Tumor marker Immunohistochemistry |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |