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Production and biomedical applications of virus-like particles derived from polyomaviruses
Authors:Erik A. Teunissen  Markus de RaadEnrico Mastrobattista
Affiliation:Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, University of Utrecht, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands
Abstract:
Virus-like particles (VLPs), aggregates of capsid proteins devoid of viral genetic material, show great promise in the fields of vaccine development and gene therapy. These particles spontaneously self-assemble after heterologous expression of viral structural proteins. This review will focus on the use of virus-like particles derived from polyomavirus capsid proteins. Since their first recombinant production 27 years ago these particles have been investigated for a myriad of biomedical applications. These virus-like particles are safe, easy to produce, can be loaded with a broad range of diverse cargos and can be tailored for specific delivery or epitope presentation. We will highlight the structural characteristics of polyomavirus-derived VLPs and give an overview of their applications in diagnostics, vaccine development and gene delivery.
Keywords:aa, amino acid   AFFFF, asymmetrical-flow field flow fractionation   APyV, avian polyomavirus   BKPyV, BK virus   bp, base pair   ChPyV, chimpanzee polyomavirus   CTL, cytotoxic T lymphocyte   DC, dendritic cell   DHFR, dihydrofolate reductase   DIVA, differentiate infected from vaccinated animals   dsDNA, double-stranded DNA   DTT, dithiothreitol   E. coli, Escherichia coli   EDTA, ethylenediaminetetraacetic acid   EGFP, enhanced green fluorescent protein   EGTA, ethylene glycol tetraacetic acid   ER, endoplasmic reticulum   FPyV, finch polyomavirus   GCV, ganciclovir   GHPyV, goose hemorrhagic polyomavirus   GRAS, generally recognized as safe   GST, glutathione S-transferase   HaPyV, hamster polyomavirus   hEGF, human epidermal growth factor   HPV, human papillomavirus   JCPyV, JC virus   LCMV, lymphocytic choriomeningitis virus   LPyV, beta-lymphotropic polyomavirus   MALS, multiple-angle light scattering   MCC, Merkel cell carcinoma   MCPyV, Merkel cell polyomavirus   MPtV, murine pneumotropic virus   MPyV, murine polyomavirus   NLS, nuclear localization signal   NP, nucleocapsid protein   NTA, nitrilotriacetic acid   OVA, ovalbumin   PBS, phosphate buffered saline   PLP, polyoma-like particle   PNA, peptide nucleic acids   PSA, prostate specific antigen   PTX, paclitaxel   PUUV, Puumala hantavirus   PyV, polyomavirus   S. cerevisiae, Saccharomyces cerevisiae   Sf, Spodoptera frugiperda   SR101, sulforhodamine 101   SV40, simian virus 40   TEM, transmission electron microscopy   VLP, virus-like particle
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