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| 琥珀酸美托洛尔缓释片的制备及犬体内外相关性研究 | |
| 引用本文： | 黄桂华,邓树海,王荣梅,席延卫. 琥珀酸美托洛尔缓释片的制备及犬体内外相关性研究[J]. 中国医药工业杂志, 2005, 36(7): 412-414 |
| 作者姓名： | 黄桂华 邓树海 王荣梅 席延卫 |
| 作者单位： | 1. 山东大学药学院药物制剂所,山东济南,250012 2. 山东大学第二附属医院药剂科,山东济南,250011 |
| 摘 要： | 采用正交试验优化琥珀酸美托洛尔缓释片处方工艺,通过UV法测定体外释放度,HPLC测定犬体内血药浓度,进行体内外相关性研究.结果表明,本品体外释放符合Higuchi方程,释药机理属扩散和溶蚀双重作用.本品体外释放和犬体内吸收相关系数为0.9873. |
| 关 键 词： | 琥珀酸美托洛尔 缓释片 体内外相关性 |
| 文章编号： | 1001-8255(2005)07-0412-03 |
Preparation and in vitro-in vivo Correlation in Dogs of Metoprolol Succinate Sustained-released Tablets |
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| HUANG Gui-hua,DENG Shu-hai,WANG Rong-mei,XI Yan-Wei. Preparation and in vitro-in vivo Correlation in Dogs of Metoprolol Succinate Sustained-released Tablets[J]. , 2005, 36(7): 412-414 | |
| Authors: | HUANG Gui-hua DENG Shu-hai WANG Rong-mei XI Yan-Wei |
| Abstract: | The formulation of metoprolol succinate sustained-released tablets was optimized using orthogonaldesign. The in vitro dissolution of the preparation and its concentration in dog plasma was determined by UV and HPLC,respectively. The results showed that the drug dissolution coincided with Higuchi equation and the release mechanism forthe preparation was a conjoint effect of diffusion and corrosion. The correlation coefficient of in vitro dissolution and invivo absorption in dogs was 0.9873. |
| Keywords: | metoprolol succinate sustained-released tablets in vitro-in vivo correction |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |