| 多囊卵巢综合征大鼠模型诱导的实验研究 |
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| 引用本文： | 夏燕,王惠仔,郑建淮. 多囊卵巢综合征大鼠模型诱导的实验研究[J]. 中国优生与遗传杂志, 2010, 0(7): 124-125 |
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| 作者姓名： | 夏燕 王惠仔 郑建淮 |
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| 作者单位： | [1]陕西省西安市第五医院妇产科,西安710082 [2]西安交通大学医学院第一附属医院生殖医学科,西安710061 |
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| 摘 要： | 目的建立多囊卵巢综合征（PCOS）大鼠模型。方法通过皮下埋置17-炔诺酮硅胶棒联合皮下注射HCG（Bogovich法）诱导PCOS大鼠模型。测定血清睾酮（T）空腹血糖（FPG）及胰岛素（FIns）水平。结果模型组胰岛素抵抗指数（Homa-IR）、FPG、Fins及T水平均高于对照组,24dPCOS大鼠模型构建成功。结论 Bogovich法诱导的PCOS大鼠模型存在高雄激素水平及代谢异常,是研究PCOS发病机制的理想动物模型。
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| 关 键 词： | 多囊卵巢综合征 动物模型 |
The rat model induced study in polycystic ovary syndrome |
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| Affiliation: | XIA Yan , WANG Hui - zi , ZHENG Jian - huai ( 1. Department of Obstetrics ＆ Gynecology The Fifth Hospital of Xi＇an Shaanxi Province, 710082, China ; 2. Department of Reproductive Medicine, The First Affiliated Hospital of Medical College, Xi＇an Jiaotong University, Shaanxi Xi＇an 710061, China ) |
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| Abstract: | Objective： To develop polycystic ovary syndrome model. Methods： PCOS model induced by Levonorgestrel Implant implanting and HCG injection. Concentrations of T, FPG, Fins and subsequent hormone have been determined by radio immunoassay. Results ： The model rats have developed PCO changes, Homa - IR T, FPG, Fins levels have dramatically higher than that of the controls. PCOS model has been induced in 24d. Conclusion： The rat model which induced by Levonorgestrel Implant implanting and HCG injection is a convincing model for PCOS study. |
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| Keywords: | Polycystic ovary syndrome Rat model |
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