| 7-苯乙酰氨基-3-吡啶甲基-3-头孢菌素-4-羧酸对甲氧苄酯的合成 |
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| 引用本文： | 陈艳荣,冯胜昔,刘厂林,田洪涛. 7-苯乙酰氨基-3-吡啶甲基-3-头孢菌素-4-羧酸对甲氧苄酯的合成[J]. 广东药学院学报, 2006, 22(3): 241-242 |
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| 作者姓名： | 陈艳荣 冯胜昔 刘厂林 田洪涛 |
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| 作者单位： | 广州白云山化学制药厂,制造部,广东,广州,510515;广州白云山化学制药厂,合成研究所,广东,广州,510515 |
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| 摘 要： | 对7-苯乙酰氨基-3-吡啶甲基-3-头孢菌素-4-羧酸对甲氧苄酯的合成工艺进行优化,结果改进工艺后可缩短生产周期4~6 h,收率达88.3%,含量97.1%。该工艺简化了操作过程,降低了生产成本,提高了生产效率,为工业化生产提供了更有利的保障。
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| 关 键 词： | 7-苯乙酰氨基-3-吡啶甲基-3-头孢菌素-4-羧酸对甲氧苄酯 合成 工业化 |
| 文章编号： | 1006-8783(2006)03-0241-02 |
| 收稿时间： | 2006-04-06 |
| 修稿时间： | 2006-06-05 |
Synthesis of 7-phenylacetyl-3-pyridiniummethyl-4-carboxylic acid p-methoxybenzyl ester |
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| CHEN Yan-rong,FENG Sheng-xi,LIU Chang-lin,TIAN Hong-tao. Synthesis of 7-phenylacetyl-3-pyridiniummethyl-4-carboxylic acid p-methoxybenzyl ester[J]. Academic Journal of Guangdong College of Pharmacy, 2006, 22(3): 241-242 |
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| Authors: | CHEN Yan-rong FENG Sheng-xi LIU Chang-lin TIAN Hong-tao |
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| Affiliation: | 1. Deptartment of Manufacture; 2. Institute of Synthetic Medicine, Guangzhou Baiyunshan Chemical Pharmaceutical Factor, Guangzhou 510515, China |
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| Abstract: | An improved process of the preparation of 7-phenylacetyl-3-pyridiniummethyl-4-carboxylic acid p-methoxybenzyl ester was described.The yield was 88.3% and purity 97.1%.The improved process could simplify the synthetic procedure,reduce the cost of production and increase the yield of the product. |
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| Keywords: | 7-phenylacetyl-3-pyridiniummethyl-4-carboxylic acid p-methoxybenzyl ester synthesis industrial production |
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