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Rectal Mucosa Damage in Rabbits After Subchronical Application of Suppository Bases |
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| Authors: | Christian De Muynck Claude Cuvelier Danny Van Steenkiste Luc Bonnarens Jean Paul Remon |
| Affiliation: | (1) R&D Department of Vandemoortele N.V., Prins Albertlaan 79, 8870 Izegem,, B-Belgium;(2) N. Goormaghtigh Institute of Pathological Anatomy, University Hospital, De Pintelaan 185, 9000 Gent,, B-Belgium;(3) Laboratory of Pharmaceutical Technology, State University of Gent, Harelbekestraat 72, 9000 Gent,, B-Belgium;(4) Present address: Laboratory of Pharmaceutical Technology, State University of Gent, Harelbekestraat 72, 9000 Gent, Belgium |
| Abstract: | The effect of suppository bases on rabbit rectal mucosa was investigated using six triglyceride bases, polyethylene glycol, and a triglyceride base combined with monoglycerides or fatty acids and methyl esters of those acids. Rectal irritation was evaluated and scored according to defined pathological features.  Pure triglycerides and a triglyceride to which a nonionic surfactant was added caused severe mucosal damage with ulceration and inflammation. Hyperemia was characteristic for irritation by polyethylene glycol suppositories. Mucosal damage by a pure triglyceride combined with monoglycerides or fatty acids and methyl esters of those acids was similar but statistically less pronounced than with all other bases. |
| Keywords: | suppositories rectum polyethylene glycol triglyceride monoglyceride fatty acids ulcer hyperemia |
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