| 病理性瘢痕组织中SDF-1、CXCR4的表达 |
| |
| 引用本文： | 杨智勇,王喜梅,牛扶幼,任力.病理性瘢痕组织中SDF-1、CXCR4的表达[J].中国美容医学,2008,17(11). |
| |
| 作者姓名： | 杨智勇 王喜梅 牛扶幼 任力 |
| |
| 作者单位： | 郑州大学第一附属医院整形外科,河南,郑州,450052 |
| |
| 摘 要： | 目的:检测病理性瘢痕组织中SDF-1、CXCR4的表达。方法:采用免疫组织化学SABC法检测58例病理性瘢痕(增生性瘢痕30例,瘢痕疙瘩28例)、30例非病理性瘢痕及28例正常皮肤组织中SDF-1、CXCR4的表达。结果:SDF-1在病理性瘢痕中的阳性表达率均高于非病理性瘢痕与正常皮肤组织(P<0.01),且在瘢痕疙瘩中的阳性表达率高于增生性瘢痕(P<0.05)。CXCR4在病理性瘢痕、非病理性瘢痕及正常皮肤组织中均为低表达或不表达,且各组间的差异均无统计学意义(P>0.05)。结论:SDF-1/CXCR4生物轴在病理性瘢痕形成过程中的作用是通过SDF-1的表达升高实现的。
|
| 关 键 词： | 病理性瘢痕 免疫组化 |
Expression of stromal cell-derived factor 1 and CXCR4 in pathologic scar tissue |
| |
| YANG Zhi-yong,WANG Xi-mei,NIU Fu-you,REN Li.Expression of stromal cell-derived factor 1 and CXCR4 in pathologic scar tissue[J].Chinese Journal of Aesthetic Medicine,2008,17(11). |
| |
| Authors: | YANG Zhi-yong WANG Xi-mei NIU Fu-you REN Li |
| |
| Abstract: | Objective To explore the expressions of SDF-1 and CXCR4 in pathologic scar. Methods The expressions of SDF-1 and CXCR4 in 58 cases of pathologic scar (30 cases of hypertrophic scar, 28 cases of keloid), 30 cases of non-pathologic scar, and 28 cases of normal skin tissue were detected using immunohistochemical method. Results The positive rates of SDF-1 in pathologic scar , non-pathologic scar, and normal skin tissue were significant different (P<0.01). The expressions of CXCR4 in pathologic scar, non-pathologic scar, and normal skin tissue had not statistical difference(P>0.05). Conclusion The up-regulation of SDF-1 may play an important role in the formation of pathologic scar. |
| |
| Keywords: | SDF-I CXCR4 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
