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Current status and prospects of clinical proteomics studies on detection of colorectal cancer: Hopes and fears
引用本文:de Noo ME,Tollenaar RA,Deelder AM,Bouwman LH. Current status and prospects of clinical proteomics studies on detection of colorectal cancer: Hopes and fears[J]. World journal of gastroenterology : WJG, 2006, 12(41): 6594-6601. DOI: 10.3748/wjg.v12.i41.6594
作者姓名:de Noo ME  Tollenaar RA  Deelder AM  Bouwman LH
作者单位:Department of Surgery Leiden University Medical Center,Leiden,The Netherlands,Department of Surgery,Leiden University Medical Center,Leiden,The Netherlands,Biomolecular Mass Spectrometry Unit,Department of Parasitology,Leiden University Medical Center,Leiden,The Netherlands,Department of Surgery,Leiden University Medical Center,Leiden,The Netherlands
摘    要:
BACKGROUND In order to improve early detection, monitor disease out-come and find targets for more individualised therapy, there is an urgent demand for new biomarkers in oncology. A f ield of recent interest is clinical proteomics, which has been reporte…

关 键 词:结肠癌  直肠癌  病理  治疗  临床
收稿时间:2006-07-13

Current status and prospects of clinical proteomics studies on detection of colorectal cancer: hopes and fears
de Noo M E,Tollenaar R A E M,Deelder A M,Bouwman L H. Current status and prospects of clinical proteomics studies on detection of colorectal cancer: hopes and fears[J]. World journal of gastroenterology : WJG, 2006, 12(41): 6594-6601. DOI: 10.3748/wjg.v12.i41.6594
Authors:de Noo M E  Tollenaar R A E M  Deelder A M  Bouwman L H
Affiliation:1. Departmentof Surgery, Leiden University Medical Center, Leiden, The Netherlands
2. Biomolecular Mass Spectrometry Unit, Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
Abstract:
Colorectal adenocarcinoma (CRC) is the third most common type of cancer and the fourth most frequent cause of death due to cancer worldwide. Given the natural history of CRC, early diagnosis appears to be the most appropriate tool to reduce disease-related mortality. A field of recent interest is clinical proteomics, which was reported to lead to high sensitivity and specificities for early detection of several solid tumors. This emerging field uses mass spectrometry-based protein profiles/patterns of easy accessible body fluids to distinguish cancer from non-cancer patients. These discrepancies may be a result of: (1) proteins being abnormally produced or shed and added to the serum proteome, (2) proteins clipped or modified as a consequence of the disease process, or (3) proteins subtracted from the proteome owing to disease-related proteolytic degradation pathways. Therefore, protein pattern diagnostics would provide easy and reliable tools for detection of cancer. This paper focuses on the current status of clinical proteomics research in oncology and in colorectal cancer especially, and will reflect on pitfalls and fears in this relatively new area of clinical medicine, which are reproducibility issues and pre-analytical factors, statistical issues, and identification and nature of discriminating proteins/peptides.
Keywords:Proteomics  Colorectal cancer  Protein profiling  Diagnosis  Biomarkers  Statistical issues
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