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| 哌唑嗪对原发性高血压病人红细胞Ca~(2+),Mg~(2+)-ATP酶和钙调素的影响 | |
| 引用本文： | 祝之明,宋克群,刘光耀,李言让,黄进,赵乐,刘群. 哌唑嗪对原发性高血压病人红细胞Ca~(2+),Mg~(2+)-ATP酶和钙调素的影响[J]. 基础医学与临床, 1989, 0(5) |
| 作者姓名： | 祝之明 宋克群 刘光耀 李言让 黄进 赵乐 刘群 |
| 作者单位： | 第三军医大学三院高血压研究室(祝之明，宋克群，刘光耀，李言让)，重庆建设厂职工医院(黄进，赵乐)，重庆建设厂职工医院(刘群) |
| 摘 要： | 本实验观察了原发性高血压(EH)病人红细胞Ca~(2+)Mg~(2+)-ATP酶活性,红细胞和血浆钙调素(CaM)的变化及哌唑嗪对其影响。结果表明:EH病人红细胞基础和最大Ca~(2+),Mg~(2+)-ATP酶活性显著下降,并与血压呈显著负相关;红细胞CaM活性也显著降低并与最大Ca~(2+),Mg~(2+)-ATP酶活性呈显著正相关;经哌唑嗪治疗后,EH病人红细胞Ca~(2+),Mg~(2+)-ATP酶活性和CaM变化不显著,但血浆CaM有所降低。提示EH病人红细胞钙代谢异常与外周阻力增高有密切关系,哌唑嗪对细胞和体液CaM有不同影响。 |
| 关 键 词： | 原发性高血压 红细胞 钙调素 Ca~(2+)Mg~(2+)-ATP酶 哌唑嗪 |
Effects of Prazosin on Ca~(2+), Mg~(2+)-ATPase Activites and Calmodulin of Erythrocyte in Essential Hypertension |
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| Zhu Zhiming,Song Kequn,et al.. Effects of Prazosin on Ca~(2+), Mg~(2+)-ATPase Activites and Calmodulin of Erythrocyte in Essential Hypertension[J]. Basic Medical Sciences and Clinics, 1989, 0(5) | |
| Authors: | Zhu Zhiming Song Kequn et al. |
| Abstract: | The changes of the Ca2+, Mg2+-ATPase activites and calmodulin (CaM) in erythrocyte, plasma CaM and the effects of prasozin on them were studied in patients with essential hypertension (EH) . The results showed that the basal and maximal Ca2+ Mg2+-ATPase activites of erythrocyte were lower in EH subjects than those in normal controls, and Ca2+, Mg2+-ATPase activities were significantly negative correlation with blood pressure, the activity of CaM in erythrocyte was also reduced, and there were highly positive correlation between CaM and maximal Ca2+ Mg2+-ATPase activity in erythrocyte. Therapy with the prasozin, the basal and maximal Ca2+, Mg2+ -ATPase and CaM activities in erythrocyte were unchanged, but plasma CaM activity reduced markedly. It indicated that abnormalities of cellular calcium have an important role in EH, and prasozin exerts a different effect on CaM activity in intra- and extracellular. |
| Keywords: | essential hypertension Ca2+ Mg2+-ATPase calmoduljn erythrocyte prasozin |
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