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Reactions of some cinnamoyl benzofuran derivatives with activated nitriles and their biological activity |
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| Authors: | H. I. El-Diwani S. S. Nakkady O. El-Shabrawy A-K. M. N. Gohar O. H. Hishmat |
| Affiliation: | 1. Natural Products Department, National Research Centre, Dokki, Cairo, Egypt 2. Pharmacology Department, National Research Centre, Dokki, Cairo, Egypt 3. Chemistry Department, Faculty of Science, Minia University, Egypt |
| Abstract: | Several 4-cyano-1-benzofuranyl-1-butanone derivatives were synthesized and screened for potential antiinflammatory and analgesic activities. The effect of structural variation of these molecules on biological activities was systematically examined. Among these compounds V a , V c and VI e were found to demonstrate a significant antiinflammatory effect. Compounds VI e , V a , I d , I b and VII f were also significantly effective as analgesic ones. |
| Keywords: | 4-Cyano-1-benzofuranyl-1-butanone derivatives antiinflammatory activity analgesic activity |
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