Screening for complement deficiency in bacterial meningitis |
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| Authors: | T Ernst,PJ Spä th,C Aebi,UB Schaad,MG Bianchetti |
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| Affiliation: | Department of Paediatrics University of Basel, Basel, Switzerland University of Basel, Basei, Switzerland;University of Bern, ZLB Central Laboratory Switzerland University of Basel, Basei, Switzerland;Department of Paediatrics Blood Transfusion Service SRC, Bern University of Basel, Basei, Switzerland |
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| Abstract: | Seventy-seven children with bacterial meningitis were screened for complement deficiency. Both the classical and the alternate pathways were normal in 75 patients. Transiently reduced total haemolytic activity of the classical pathway was documented in a boy with meningococcal meningitis. Total haemolytic activity of both the classical and the alternate pathways were reduced in another patient with pneumococcal meningitis: individual complement components determination indicated predominant activation of the alternate pathway. |
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