Intracystic papillary carcinoma of the breast: A SEER database analysis of implications for therapy |
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| Affiliation: | 1. Wake Forest School of Medicine, Department of Surgery, Section of Surgical Oncology, USA;2. Wake Forest School of Medicine, Department of Radiation Oncology, USA;3. Wake Forest School of Medicine, Department of Biostatistics, USA;1. Department of Radiology, Lenox Hill Hospital, New York, NY;2. Department of Pathology, Lenox Hill Hospital, New York, NY;1. Department of Physics and Astronomy, Uppsala University, 751 20 Uppsala, Sweden;2. Institute for Molecular Science, Nishigo-Naka 38, Myodaiji, Okazaki 444-8585, Japan;3. Physics Department, Stockholm University, 106 91 Stockholm, Sweden;4. Department of Chemistry, Physical and Theoretical Chemistry Laboratory, Oxford University, South Parks Road, Oxford OX1 3QZ, United Kingdom;5. Institute for Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai 980-8577, Japan;6. Department of Physics, Gothenburg University, 412 96 Gothenburg, Sweden;1. Department of Neurological Surgery, University of California at San Francisco, San Francisco, CA, USA;2. Department of Pathology, University of California at San Francisco, San Francisco, CA, USA;3. Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, 676 N. St. Clair St, Suite 2210, Chicago, IL 60611-2911, USA |
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| Abstract: | ![]()
BackgroundIntracystic papillary carcinoma (IPC) of the breast is a rare breast malignancy with an indolent course. However, patients can develop metastatic disease. Indications for surgery and radiotherapeutic management have not been well elucidated.MethodsWe identified 2649 female patients with IPC from the Surveillance, Epidemiology, and End Results (SEER) registry. Differences in demographics, clinical features and survival of patients were assessed using the Kaplan–Meier method and Cox regression.ResultsMedian age was 67 years. The majority of patients were white with Stage 0 disease. Most patients had lymph node evaluation and only 34% received radiation therapy. Using a log-rank test, survival was significantly better in Caucasian compared to African-American patients, patients with early stage disease, negative lymph nodes and those who received radiation (all p < 0.0001). In a Cox regression survival model adjusting for age, stage and grade, patients who were African-American (hazard ratio [HR] 2.0, CI 1.4–2.8; p < 0.0001) had a significantly higher risk of death than Caucasians. Patients who received radiation therapy (HR 0.5, CI 0.3–0.7; p = 0.0003) had a lower chance of death than patients that did not undergo radiation.ConclusionOverall, IPC has a good prognosis. Survival is improved in Caucasian patients and in patients who receive radiation therapy. Radiation therapy should be offered to women with IPC who undergo breast conserving surgery. |
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| Keywords: | Intracystic papillary carcinoma Breast cancer SEER IPC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0030" }," $$" :[{" #name" :" text" ," _" :" intracystic papillary carcinoma |
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