Changing pattern in the clinical presentation of breast cancer in the absence of a screening program over a period of thirty-three years in Iran |
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| Affiliation: | 1. Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;2. Cancer Research Center, Mashhad, Iran;1. Department of Surgery, Boston Children''s Hospital and Harvard Medical School, Boston, MA, USA;2. Department of Surgery, Brigham and Women''s Hospital and Harvard Medical School, Boston, MA, USA;3. Department of Paediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA;4. Department of Epidemiology and Cancer Control, St. Jude Children''s Research Hospital, Memphis, TN, USA;5. Harvard T.H. Chan School of Public Health, Boston, MA, USA;6. Department of Surgery, St. Jude Children''s Research Hospital, Memphis, TN, USA;7. Survivorship Clinic, Department of Hematology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel;8. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, USA;9. Clinical Research and Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA;10. Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;11. Department of Medicine, Duke University School of Medicine, Durham, NC, USA;1. Department of Human Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical University, Changsha, PR China;2. Xiangya Hospital, Central South University, Changsha, PR China;3. School of Basic Medical Science, Changsha Medical University, Changsha, PR China;4. Key Laboratory for Fertility Regulation and Birth Health of Minority Nationalities of Yunnan Province, Judicial Expertise Center, Yunnan Population and Family Planning Research Institute, Kunming, PR China;1. Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, AK, USA;2. Center for Immunization and Respiratory Infectious Diseases, Public Health Agency of Canada, Ottawa, Canada;3. The National Board of Health, Government of Greenland, 3900 Nuuk, Greenland;4. National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada;5. Provincial Laboratory for Public Health (Microbiology), Walter Mackenzie Health Sciences Centre, Edmonton, Alberta, Canada;1. Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas;2. Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, Texas;4. Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas;3. Department of Clinical Oncology and Nuclear Medicine, University of Alexandria, Alexandria, Egypt;1. Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York;2. Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York;3. Department of Nuclear Medicine, Memorial Sloan Kettering Cancer Center, New York, New York;4. Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, New York;6. Department of Surgery, Temple University School of Medicine, Philadelphia, Pennsylvania;1. Department of Pathology, Hospital Universitario Central de Asturias, Oviedo, Spain;4. Unit of Dermatopathology, Hospital Universitario Central de Asturias, Oviedo, Spain;5. Service of Dermatology II, Hospital Universitario Central de Asturias, Oviedo, Spain;6. Department of Otolaryngology, Instituto Universitario de Oncología del Principado de Asturias, Hospital Universitario Central de Asturias, Oviedo, Spain;2. Geisel School of Medicine at Dartmouth, Dartmouth College, Hanover, New Hampshire;3. Universidad Autónoma de Chile, Santiago, Chile |
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| Abstract: | ObjectiveTo survey the proportion of stages at the presentation of the disease without a screening program, among a population of breast cancer patients that is as a representative sample of the country in a distinct period.Materials and methodsThe population of the current study is found among the female breast cancer patients who were referred to oncology centers in northeastern Iran over a thirty-three-year period from 1980 to 2012.ResultsFour thousand patients were divided into three time periods consisting of 521 cases from 1980 to 1990, 1178 cases from 1991 to 2001, and 2302 cases from 2002 to 2012. While there was no difference in the proportions of T1 and T3 tumors, T2 tumors showed an increase (P = 0.001) and T4 tumors a decrease (P = 0.000) during these periods. There was no change in the proportion of stage I, however the proportion of stage II had risen (P = 0.000), while that of stage III (P = 0.002), and stage IV (P = 0.000) had fallen. The study's urban and rural populations experienced a similar trend in this respect, with the exception that the rural population exhibited more striking changes during the study's recent years.ConclusionAfter a thirty-three-year follow up on breast cancer in northeastern Iran, it is obvious that this disease is now presented in its earlier stages even in the absence of a screening program. In spite of this, the proportion of T1 disease and those tumors are discovered by a screening program has not significantly changed. |
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| Keywords: | Breast cancer Screening Stage of disease Iran |
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