Evaluating the effect of Matricaria recutita and Mentha piperita herbal mouthwash on management of oral mucositis in patients undergoing hematopoietic stem cell transplantation: A randomized,double blind,placebo controlled clinical trial |
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| Institution: | 1. Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran;2. Taleghani Bone Marrow Transplantation Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;3. Student Research Committee, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran;4. Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;5. Department of Pharmacognosy, School of Pharmacy and, Shahid Beheshti University of Medical Sciences, Tehran, Iran;6. Pharmaceutical sciences research center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;1. Christus University Center – UNICHRISTUS, Fortaleza, Brazil;2. Ceara State University - UECE, Fortaleza Brazil;1. Department of Medical Oncology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China;2. Department of Hematology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China;3. Gastrointestinal Institute, the Sixth Affiliated Hospital of Sun Yat-sen University, 26# YuanCun ErHeng Road, Guangzhou 510655, China;1. Baskent University Adana Adult Bone Marrow Transplantation Center, Adana, Turkey;2. Antalya Medical Park Transplant Center, Antalya, Turkey;3. Erciyes University Sahinur Dedeman Transplantation Center, Kayseri, Turkey;1. Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran;2. Department of Traditional Medicine, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran;3. Department of Traditional Persian Medicine, School of Traditional Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;4. Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;5. Essence of Parsiyan Wisdom Institute, Traditional Medicine and Medicinal Plant Incubator, Shiraz University of Medical Sciences, Shiraz, Iran;6. Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran;7. Pharmaceutical Sciences Research Center and Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran;8. Research Office for the History of Persian Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;1. Department of Nursing, Chang Gung University of Science and Technology, Taoyuan, Taiwan;2. School of Nursing, College of Medicine, National Taiwan University, Taipei, Taiwan;3. Department of Radiation Oncology, Chang Gung Medical Foundation, Chang Gung Memorial Hospital at LinKou and Department of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan;4. Head and Neck Oncology Group, Chang Gung Medical Foundation, Chang Gung Memorial Hospital at LinKou, Taoyuan, Taiwan;1. Community-Based Psychiatric Care Research Center, Department of Medical Surgical Nursing, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran;2. Hematology Research Center, Department of Hematology and Medical Oncology, Shiraz University of Medical Sciences, Shiraz, Iran |
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| Abstract: | ObjectivesTo investigate the effects of Matricaria recutita and Mentha piperita on oral mucositis (OM) in patients undergoing hematopoietic stem cell transplantation (HSCT).DesignRandomized double blind placebo controlled clinical trial.SettingFaculty of Pharmacy, Shahid Beheshti University of Medical Sciences, and Bone Marrow Transplantation Center at Taleghani Teaching Hospital, Tehran, Iran.ParticipantsSixty patients undergoing HSCT were randomly assigned to two groups: placebo (n = 33), and herbal mouthwash group (n = 27).InterventionsAll patients received the mouthwash one week before HSCT and were instructed to use it three times daily for at least 30 s.Main outcome measuresOM was graded using National Cancer Institute Common Toxicity Criteria (NCI-CTC) scale (grade 0–5). The Numerical Rating Scale (NRS: 0–10 scale) measured the severity of OM symptoms.ResultsThe duration, maximum and average daily grade of OM were significantly reduced in the treatment group (P < 0.05). The use of herbal mouthwash led to significant improvements in pain intensity (P = 0.009), dryness (P = 0.04) and dysphagia (P = 0.009). Other significant results included: reduced need for complementary medications (P = 0.03), narcotic analgesics (P = 0.047), total parenteral nutrition (TPN) (P = 0.02) and the duration of TPN (P = 0.03).ConclusionThis study shows that patients receiving the herbal mouthwash experienced less complications and symptoms associated with OM. In summary, it seems that the use of our prepared herbal mouthwash is beneficial for patients undergoing HSCT. |
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| Keywords: | Hematopoietic stem cell transplantation Oral mucositis Matricaria recutita Mentha piperita Mouthwash Herbal preparation |
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