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Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities
Authors:Carl M. Gay  C. Allison Stewart  Elizabeth M. Park  Lixia Diao  Sarah M. Groves  Simon Heeke  Barzin Y. Nabet  Junya Fujimoto  Luisa M. Solis  Wei Lu  Yuanxin Xi  Robert J. Cardnell  Qi Wang  Giulia Fabbri  Kasey R. Cargill  Natalie I. Vokes  Kavya Ramkumar  Bingnan Zhang  Lauren Averett Byers
Affiliation:1. Department of Thoracic/Head & Neck Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA;2. Department of Bioinformatics and Computational Biology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA;3. Department of Biochemistry, Vanderbilt University Medical Center, Nashville, TN, USA;4. Department of Oncology Biomarker Development, Genentech Inc., South San Francisco CA, USA;5. Department of Translational Molecular Pathology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA;6. AstraZeneca, Waltham, MA, USA;7. Department of Precision Medicine, Oncology Division, University of Campania “Luigi Vanvitelli”, Naples, Italy;8. The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA;9. Department of Thoracic and Cardiovascular Surgery, the University of Texas MD Anderson Cancer Center, Houston, TX, USA;10. Department of Internal Medicine and Simmons Cancer Center, the University of Texas Southwestern Medical Center, Dallas, TX, USA
Abstract:
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  • Keywords:SCLC  neuroendocrine  ASCL1  NEUROD1  POU2F3  EMT  intratumoral heterogeneity
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