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Melanoma models for the next generation of therapies
Authors:E. Elizabeth Patton  Kristen L. Mueller  David J. Adams  Niroshana Anandasabapathy  Andrew E. Aplin  Corine Bertolotto  Marcus Bosenberg  Craig J. Ceol  Christin E. Burd  Ping Chi  Meenhard Herlyn  Sheri L. Holmen  Florian A. Karreth  Charles K. Kaufman  Shaheen Khan  Sebastian Kobold  Eleonora Leucci  Carmit Levy  Glenn Merlino
Affiliation:1. MRC Human Genetics Unit and Cancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK;2. Melanoma Research Alliance, 730 15th Street NW, Washington, DC 20005, USA;3. Experimental Cancer Genetics, Wellcome Sanger Institute, Hinxton, Cambridge CB10 1SA, UK;4. Department of Dermatology, Meyer Cancer Center, Program in Immunology and Microbial Pathogenesis, Weill Cornell Medicine, New York, NY 10026, USA;5. Department of Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA;6. Université Côte d’Azur, Nice, France;7. Departments of Dermatology, Pathology, and Immunobiology, Yale University, New Haven, CT, USA;8. Program in Molecular Medicine and Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, USA;9. Departments of Molecular Genetics, Cancer Biology, and Genetics, The Ohio State University, Biomedical Research Tower, Room 918, 460 W. 12th Avenue, Columbus, OH 43210, USA;10. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA;11. The Wistar Institute, Philadelphia, PA, USA;12. Department of Surgery, University of Utah Health Sciences Center, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA;13. Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA;14. Washington University School of Medicine, Department of Medicine, Division of Oncology, Department of Developmental Biology, McDonnell Science Building, 4518 McKinley Avenue, St. Louis, MO 63110, USA;15. Department of Pathology, UT Southwestern Medical Center, Dallas, TX, USA;16. Center of Integrated Protein Science Munich (CIPS-M) and Division of Clinical Pharmacology, Department of Medicine IV, Klinikum der Universität München, LMU, Munich, Germany;17. Laboratory for RNA Cancer Biology, Department of Oncology, LKI, KU Leuven, 3000 Leuven, Belgium;18. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel;19. Department of Pathology, Institute of Gerontology, and Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA;20. Ronald O. Perelman Department of Dermatology and Department of Pathology, NYU Grossman School of Medicine, New York, NY 10016, USA;21. Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA;22. Laboratory for Molecular Cancer Biology, Center for Cancer Biology, VIB, Leuven, Belgium;23. CRUK Manchester Institute, The University of Manchester, Alderley Park, Macclesfield SK10 4TG, UK;24. Department of Dermatology & Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA;25. Laboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Campus Juriquilla, Boulevard Juriquilla 3001, Santiago de Querétaro 76230, Mexico;26. Cancer Center, Sanford Burnham Medical Discovery Institute, La Jolla, CA 92037, USA;27. Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel;28. Spanish National Cancer Research Centre, 28029 Madrid, Spain;29. The Wistar Institute, Molecular and Cellular Oncogenesis Program, Philadelphia, PA, USA;30. Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, and Department of Oncology, Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA;31. Department of Cancer Biology & Genetics and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA;32. Departments of Dermatology and Pathology, University of California, San Francisco, CA, USA;33. Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA, USA;34. Stem Cell Program and Division of Hematology/Oncology, Boston Children''s Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Medical School, Harvard Stem Cell Institute, Stem Cell and Regenerative Biology Department, Harvard University, Boston, MA, USA;35. Center for Cancer Research, NCI, NIH, 37 Convent Drive, Bethesda, MD 20892, USA;36. INSERM, Biology and Pathologies of Melanocytes, Team 1, Equipe Labellisée Ligue 2020, Centre Méditerranéen de Médecine Moléculaire, Nice, France;37. Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY, USA;38. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA;39. Department of Medicine, Weill Cornell Medical College, New York, NY, USA;40. Laboratory for Molecular Cancer Biology, Department of Oncology, KU Leuven, Leuven, Belgium;41. Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK;42. Member of the German Center for Lung Research (DZL), German Center for Translational Cancer Research (DKTK), partner site Munich, Munich, Germany;43. Trace, Department of Oncology, LKI, KU Leuven, 3000 Leuven, Belgium
Abstract:
Keywords:melanoma  drug discovery  animal models  therapeutics  immunotherapy  targeted therapy  tumor microenvironment
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